Award Data

Frederick T. Elder & Associates(FTEA) proposes an approach to the development of a closed-cycle Helium-Rubidium(He-Rb) circulator that allows for FTEA to ensure safety throughout the project, to manufacture a prototype at a reasonable cost using mostly commercial components if selected for Phase II, and to meet or exceed the requirements outlined in the solicitation. FTEA has considered existing D ...

We propose to design and implement a query-based approach to interoperable modeling and simulation of composite material structures, that usually contain the manufacturing recipe within their design. In Phase I, we established the feasibility of the approach using a demonstration scenario of CAD/CAE interoperability for assemblies. In Phase II, we propose to develop a series of use-case scenarios ...

In the proposed Phase II Enhancement, Prism Computational Sciences, Corvid Technologies, and Bodkin Design and Engineering will perform experimental and simulation studies of the optical emission from impact flash events. This collaboration builds on the SBIR Phase II efforts of the Prism-Corvid team to apply high-fidelity simulation tools to study impact flash line emission from laboratory gas-g ...

DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. Innovative synthetic biology methods will overcome ...

DESCRIPTION (provided by applicant): The goal of this project is to develop functional magnetic resonance imaging (fMRI) tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology. The specific focus of this proposal is to produce a practical, clinic-ready suite of MR imaging methods, analyses and display tools to solve the number one impediment to ...

DESCRIPTION (provided by applicant): The diagnosis and treatment of patients with brain tumors and other diseases is often critically dependent on functional neuroimaging (e.g. fMRI) to identify healthy brain tissue that must be avoided during invasive surgery or radiation treatment. But, conventional fMRI often fails (up to 30 percent) or cannot be used with patients who are unable to adequately ...

DESCRIPTION (provided by applicant): The goal of this project is to develop and evaluate a position tracking and mobility assessment system that will enable the elderly to live longer and more safely at home or in an assisted living facility. The ability to move is a critical function tat underlies the quality of life for the elderly. Changes in mobility such as speed of walking have been shown to ...

DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently, accurately, or sensitively. Our long-term goal is to develop and commercialize a unique system called the Hom ...

Significance: Accurate targeting, guidance and monitoring of interventional therapy in the brain are critical for maximizing the effectiveness and safety during and following neurosurgical procedures. Magnetic resonance imaging (MRI) is a critical tool forplanning and guiding neurosurgical procedures. In most cases, the MRI is obtained during a pre-operative session; however, either brain shift, e ...

DESCRIPTION (provided by applicant): Marital discord is a significant risk factor for a range of negative mental and physical health outcomes.1, 2 Individuals in unhappy relationships experience increases in stress, anxiety, functional impairment, and depressive symptoms3 and are at significant risk for substance abuse disorders.4-7 Furthermore, work loss associated with marital problems translate ...