Award Data

PROJECT SUMMARY In the United Statesaortic aneurysmal disease ranks among the topleading causes of deathPatients with aortic aneurysmsAAsare typically asymptomatic until dissection and then symptoms resemble other ailmentswhich can delay a correct diagnosisMortality associated with aortic dissectionADis high and rapid due to rupture of the aortaReducing mortality from aneurysmal disease requires i ...

Summary AbstractYouth under ageinvolved in the criminal justice system are disproportionately minorities and affected by substance abusemental illnessand HIV STIMost young offenders are released on community supervision without the STImental healthor substance use screeningdiagnosisand treatment afforded detained youthdespite similar rates of risk behaviorTheir long term trajectory is poorthe cost ...

Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations often arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e., “deviant peer clustering”). Even though the field has developed efficacious school-based prevention programs, program effects are generally small, and t ...

ABSTRACT SignificanceThere are overmillion people with insulin treated diabetes in the United States who represent a disproportionately large share of the $B in direct medical costs attributable to diabetesThe use of continuous glucose monitoringCGMhas been shown to reduce HbA c levelsa proven predictor of health outcomes within this populationwith the greatest improvement achieved when CGM is cou ...

Project Summary!Parents who have children with developmental disabilitiesDDcommonly experience high levels of stress related to child behavior problems and contextual issues related to the childandapos s disability that can have a detrimental effect on their parentingCurrent stress management programs for this population of parents often do not lead to a reduction in childrenandapos s behavior pro ...

The identification and quantification of biological macromolecules remain challenging despite major advances in the speedresolution and mass accuracy of modern mass spectrometersA key weakness with current instrumentation lies in the methods used to induce fragmentationThe reliance in particular on collision induced dissociationCIDhas limited such analyses to bottom up workflows of trypsin digeste ...

ABSTRACT Manual analysis of biomedical images by researchers and pathologists has the potential to introduce bias and error that compromise the reliability of research and clinical findingsThese problems are significant barriers to delivering the most beneficial evidence based medicinedeveloping effective medical treatmentsand promoting confidence in scientific inquiryIdentification of biomarkers ...

Project Summary Abstract SignificanceOne of healthcare s largest challenges is that many patients do not respond to treatmentBy recent estimatesaroundof drugs are effective for less thanof patientsThis causes enormous physicalsocialand economic sufferingThe annual cost of ineffective treatment is estimated at $billion per year in the US aloneMoreovervariable treatment response contributes to the r ...

epilepsome phaseJanGoogle Docs Technical Summary Epilepsy is a significant health problem affectingof the human populationGenome wide DNA sequencingwhich is now being adopted in clinical practicehas led to the identification of an increasing number of variants a in epilepsy associated genesHoweverclinical interpretation of the new variants is challengingSome of the variants are known to be either ...

SUMMARY AUDIOBOOK FOR HEARING LOSS There is a growing consensus that hearing lossHLcannot be addressed with hearing aidsHAsor cochlear implantsCIsaloneauditory training is also neededWhile face to face auditory training is availablethis intervention is generally not covered by insurance plansAuditory training Apps have become available to fill this need in a cost effective mannerUnfortunatelyevide ...