Award Data

PROJECT SUMMARY/ABSTRACTAfrican American men have the highest rate of hypertension (HTN) in the United States. Once diagnosed, they are also less likely to achieve blood pressure (BP) control. This health disparity is critical, as elevated BP is the primary modifiable risk factor for cardiovascular disease. One reason for this HTN disparity: stress. African Americans report more stress than their ...

ABSTRACT An increased incidence of various pre-existing conditions like diabetes and hypertension, combined with systemic issues surrounding the quality of maternal health care provided, has resulted in a significant increase in the cesarean delivery rate in minority communities. These surgical procedures contribute to disparities in maternal health outcomes and postoperative complications, as C-s ...

Abstract Meniscus tears are among the most common orthopedic injuries, with about 1 million occurring in the United States each year and growing at a rate of 5% annually. Shortcomings associated with the current standard of care leaves a clinical need for a new treatment option. The meniscal tissue can only be repaired in limited cases due to its healing capacity, so the most common treatment for ...

A First-in-class Topical Immunoregulatory Therapeutic for Psoriasis BioTherapeutics Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computational modeling with translational experimentation to accelerate the development of novel product candidates for precision immunology. An unmet clinical need for safer, more effective drugs for plaque psoriasis remai ...

PROJECT SUMMARY Circadian rhythms play a vital role in promoting maternal health and managing pregnancy outcomes, including gestational diabetes, preterm birth, and postpartum depression. However, interventions to mitigate circadian rhythms disruption during pregnancy are lacking, despite readily available non-pharmacological circadian interventions. The circadian timekeeping system is strengthene ...

SCI incidence ranges from 250k-500k globally/year, with rt7M people impacted. Currently rt300k U.S. individuals live with SCI. SCI results in life-altering consequences in terms of morbidity, mortality, functional status, employment, and quality of life. For quadriplegics with cervical injuries, even basic ADLs are severely compromised. Individuals learn assistive strategies for ADLs such as eatin ...

Alzheimer's disease (AD) is a devastating and progressive disease without a cure. Neuroinflammation is now recognized as a key early event in the development of AD. Aberrant neuroinflammatory response activates immune cells that can increase oxidative stress, and oxidative stress can directly damage neurons and axons, cause demyelination, and break down the blood-brain barrier (BBB). Thus, damagin ...

PROJECT SUMMARYAlzheimer’s Disease (AD) affects millions of Americans, yet there are no treatments that meaningfully affect disease progression once symptoms manifest. This has shifted the focus to early detection and intervention, which is thought by many researchers to offer the best chance of slowing or stopping the progression of AD. However, trials aimed at averting the underlying causes of ...

Project Summary/AbstractRural Americans face numerous health disparities compared to their urban counterparts and are more likely to die from chronic health conditions, including substance abuse. Indeed, opioid-related mortality is highest in certain rural areas of the U.S., including Appalachia, New England, and the mountain west. A number of studies looking at morbidity and mortality provide ins ...

Project Summary/Abstract The Tiny Cargo Company offers a unique, orally administered medical countermeasure for treatment and prevention of the gastrointestinal (GI) side effects of cancer radiation therapy (RT). Our therapeutic is comprised of milk-derived extracellular vesicles (mEVs) loaded with a safe and highly effective radioprotective drug – a formulation that we call Milactatm. RT compli ...