Award Data

Our nation faces increasing challenges in meeting the special needs of elderly and disabled individuals. Non-ambulatory persons with visual impairment, diminished upper-body mobility, spasticity/tremors, memory/attention deficits and other problems may require extraordinary care measures because they can operate neither powered nor manual wheelchairs successfully. Current state-of-the-art motorize ...

DESCRIPTION (provided by applicant): Conservative estimates suggest that over 2 million people annually in the U. S. alone suffer from ulcers, and the base of those so afflicted is likely to increase in view of an aging population. Mean hospital charges of patients with a primary diagnosis for pressure ulcers were about $22,000 in 1992, a significant cost that will become increasingly difficult to ...

DESCRIPTION (provided by applicant): Endocrine disrupting compounds (EDCs) in the environment can cause a variety of physiological problems in animals and humans. Thus, measurement and analysis of EDCs in the environment is very important to the Environmental Protection Agency (EPA) in its Superfund monitoring activities. The investigators have developed a prototype macroarray that works excepti ...

DESCRIPTION (provided by applicant) This project will develop an artificial intelligence to provide the core functionality for virtual reality and computer based treatments for anxiety disorders. The use of artificial intelligence offers a number of advantages over existing treatments: (1) artificial intelligence provides personalized treatment - using multiple real time physiologic and subjective ...

DESCRIPTION (provided by applicant): The primary objective is to determine the relationship between clinical growth in pubertal girls and boys and shifts in the irregularity of underlying growth hormone (GH) secretory patterns. Novel clarifications of this time-evolution could be significant in determining the proper timing of hormone replacement therapies in pathophysiological settings such as T ...

The goal of this effort is to develop a novel label-free detection technology for application to protein microarrays. The objective of the Phase I is to build a breadboard prototype to characterize the performance of this new approach and to establish feasibility. The technology is based on a multilayer grating-coupled (MGR) evanescent wave sensing method with the potential to provide highly mul ...

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A microarray-based system for label-free, high throughput protein expression in profiling in very small volumes of tissue or blood (approximately 10 mL) is proposed. The system will consist of an instrument, and a proteomic biosensor chip integrated into a fluidics cartridge. It utilizes a novel grating-coupled surface plasmon resonance (GC-SPR) imaging technology that will enable measurement of t ...

DESCRIPTION (provided by applicant)The broad objective of this Fast Track project is to develop and commercialize a versatile and inexpensive CCD-based system for microarray imaging and quantification. A differentiating feature of this system will be the capability to perform time-gated imaging, which will provide the benefits of effective background suppression on certain substrates such as membr ...

DESCRIPTION (provided by applicant): An intraoperative surgical probe using a mercuric iodide radiation detector is proposed. The probe will have the ability to simultaneously measure the 140 keV gamma-ray emission and the 18 keV x-ray emission from Tc-99m. Good energy resolution is necessary for the lower energy x-rays to separate them from the potentially large scatter background. Comparison of ...