Award Data

DESCRIPTION (provided by applicant): Barrier membranes are an important adjunct to regeneration therapy aimed at restoring the form and function of the mouth. Commercially available barrier membranes are used in dental surgeries to help retain bone grafting materials, to help exclude epithelium and connective tissue from entering into sites of desired bone and ligament regeneration, or for the com ...

DESCRIPTION (provided by applicant): We propose to identify an optimal short carbon chain lipid species to be used as a surrogate for membranes in a novel and improved blood coagulation factor assays that will improve rapid diagnosis of coagulation disorders. Blood coagulation protects the integrity of damaged blood vessels and is localized specifically to cells at a site of injury by exposure of ...

DESCRIPTION (provided by applicant): Microfluidic technologies are an excellent candidate to achieve the goal set forth by NHGRI to reduce the total sequencing cost by two- or four-orders of magnitude from the current cost of sequencing a human-sized genome. Microfluidic chips enable highly reduced use of the sample/reagent and integration of all sequencing steps from sample preparation to separat ...

DESCRIPTION (provided by applicant): We propose to develop and demonstrate a novel microfluidic device and assay for selection and optimization of drug delivery vehicles, specifically non-viral vectors for drug delivery to tumors. Tumor drug delivery is a complex phenomenon affected by several elements in addition to drug or delivery vehicle's physico-chemical properties. A primary factor is tumor ...

DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast with current large-sized, static incubation techniques, our proposed device comprises of a microfluidic two-compartment chamber. The chamber is designed in such a way as to p ...

DESCRIPTION (provided by applicant): Hypertension is a confounding multifactorial disorder that affects millions of patients worldwide. Cystic fibrosis (CF) is an inherited disease of the pulmonary and gastrointestinal systems that presents in pediatric and young adult populations. What do hypertension and cystic fibrosis (CF) have in common? The central common feature is enhanced absorptive sodiu ...

DESCRIPTION (provided by applicant): In this proposed Phase I SBIR program, DiscoveryBioMed, Inc. (DBM) will continue to build upon an active project performed in collaboration with CFTR cell biologists at the University of Alabama at Birmingham and alternative rescue chloride (Cl-) channel physiologists at Johns Hopkins University School of Medicine. DBM developed a novel and simple SPQ halide-se ...

DESCRIPTION (provided by applicant): Analyzing dietary intake plays a central role in research that seeks to clarify the role of diet in the development of chronic disorders, such as obesity, coronary heart disease, cancer, and diabetes. In addition to its important role in research, dietary assessment also has commercial applications. As members of the general public have become more health consc ...

DESCRIPTION (provided by applicant): Radiation exposure of nuclear workers is not only a serious health and safety issue, but also imposes substantial costs on nuclear utilities. Precise knowledge of the radiation environment within a nuclear facility is essential to minimizing personnel exposure. In recent years, there has been an emphasis on remote monitoring technology (RMT) in the nuclear indu ...

DESCRIPTION (provided by applicant): Temporomandibular Disorders (TMD) usually represent a collection of medical and dental conditions affecting the temporomandibular joint (TMJ) and/or the muscles of mastication, as well as contiguous tissue structures. For some patients with severe TMJ degeneration, a prosthetic replacement may be required. However, long-term success and functioning of current i ...