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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of Rapid Antigen Detection Assays For Taeniasis

    SBC: Kephera Diagnostics, LLC            Topic: ODCDC

    This proposal addresses the significant public health threat posed by the spread of Taenia soliumthe pork tapewormin at risk human populationsInfection with Tsoliumor Taeniasiscan lead to Cysticercosiscaused by the migration and encystment of larval Tsolium in the central nervous systemCysticercosis is a severe to fatal disease which affects overmillion people worldwideprincipally in less develope ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Synergistic Antifungal Cocktails for Corneal Storage

    SBC: Giner, Inc.            Topic: ODCDC

    Fungal endophthalmitis is an infection inside the eye after corneal transplant surgery caused by contamination of the transplanted tissueAccording to the Eye Bank of Americathe incidence of postsurgery endophthalmitis more than doubled fromtoand thatof the culture positive cases were due to Candida yeastEnvironmental contamination as well as current corneal preservation conditions contribute to th ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Topic 378: PRORAD- A Mobile Application for Patient Related Outcomes of Radiotherapy

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer patients receiving radiation therapy experience toxic side effects of the radiation, and sensitivity to radiation is variable across both patients and tumors, and is poorly understood. This Phase I SBIR project aims to design and demonstrate the feasibility of a Patient Reported Outcome mobile application for surveillance of RADiotherapy toxicity (PRORAD) that integrates NIH's Patient Repor ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 374: Sustained Delivery of PARP Inhibitors for Cancer Chemoprevention

    SBC: TheraNano LLC            Topic: NCI

    Here we propose to study two injectable formulations that provide different delivery routes for Talazoparib, potent PAPR inhibitor: An implant, InCeT-Talazoparib, which can be injected directly in the tumor where it will act as a sustained release depot of Talazoparib over a prolonged period of approximately 30 days. It delivers 100% of the drug to the tumor site with almost no systemic toxicity. ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 343- Cognitive Assessment and Monitoring Platform For Integrative Research (CAMPFIRE II)

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Scriptmate: A patient-centered mobile system for geriatric prescription medication management

    SBC: DIMAGI, INC.            Topic: NIA

    PROJECT SUMMARY Elderly patients are the largest consumers of prescription and non prescription medications and have been reported to account for $million in treatment costs for medication errors likely due to altered pharmacokineticspolypharmacydecline in cognitionand lower health literacyAs a result of this confluence of issues that affect the aging populationmedication management tools designed ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Small Molecule Treatments to Enhance Neurological Recovery After Stroke

    SBC: Stemetix, Inc.            Topic: NINDS

    PROJECT SUMMARYStroke is a major public health problem in the U Sand worldwideIt is defined as an area of brain damagegenerally due to the sudden occlusion of an artery in or leading to the brainStroke can cause weaknessnumbnessvisual disturbancespeech difficultybalance problemsand memory lossamong other symptomsWhile good treatments exist to limit stroke in the first few hours after occurrencefew ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Preclinical development of Novo29, a new antibiotic


    Abstract The overall goal of this project is to conduct preclinical studies on Novoour newly discovered bactericidal compoundAs drug resistance continues to spreadnew classes of antibiotics are needed to combat infections by pathogens such as methicillin resistant Staphylococcus aureusMRSAand vancomycin resistant EnterococciVRENovois a novel class of peptidoglycan synthesis inhibitor with favorabl ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. FAST platform for same-shift, complete antibiotic menu antibiotic susceptibility testing

    SBC: SeLux Diagnostics            Topic: R

    The goal of this Phase I SBIR proposal is to demonstrate utility to all major pathogenic bacterial strains of SeLux s rapidlow costphenotypic antibiotic susceptibility testASTsystemfast AST or FASTUtilizing existing optical detectors and standard dried antibiotic microplatesand avoiding pitfalls of metabolic probesFAST will potentially transform therapy of infections by significantly accelerating ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Humanized Anti-Renalase Antibodies for Unresectable Melanoma

    SBC: BESSOR PHARMA, LLC            Topic: 102

    Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

    SBIR Phase I 2018 Department of Health and Human Services

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