Award Data

Project Summary Opioids like morphine and hydrocodone are generally the most effective therapeutics for treatment of moderate to severe pain. However, their use is limited by serious side effects - tolerance, constipation, respiratory depression, physical dependence and high addictive potential. The frequency of clinical pain, coupled with a lack of alternative therapeutic options has led to a nat ...

Physical Science Inc. (PSI) will develop a new approach to chemical vapor detection based on a novel open-path sample cell design. The PhaseI system level model predicts SNR supporting a probability of detection of 95% and a MTBFA of 168 hours for all relevant CWAs and TICs at the10 minute negligible MEG level at a 20 s measurement time. In addition to robust detection, the system design can provi ...

Poor air quality represents a major public health risk, contributing to an estimated one of every eight deaths worldwide. Low-cost air quality sensors have developed rapidly over the last few years and offer the opportunity to make air quality monitoring widespread at an affordable price. However, low-cost sensors are currently unable to deliver accurate, reliable data due to a lack of understandi ...

Triton Systems, Inc. proposes development of the Open-Source Oceanographic Asset Recovery Beacon (OpenORB) that will allow the deployment of coastal instrumentation moorings with affordable protection against loss. This open-source kit would significantly reduce the purchase price of a commercial location beacon by allowing the end-user to assemble a customized system with minimal time and effort. ...

The contractor will develop specific guidewire devices to ease and simplify transcaval access to the aortato make the procedure available to a wider range of patients and operatorsThe goal is to develop a tapered guidewire and a connector switch to a common electrosurgery generator to simplify transcaval access to the aortaUnder Phase I the contractor will develop and test a suite of working proto ...

The objective of this Phase II SBIR contract and subsequent Phase III effort is to develop and commercialize acompleteautonomous drone based system for moving microplatesand similar lab consumableswithin HighThroughput ScreeningHTSlaboratoriessupplementing and perhaps eventually replacing robotic arms whichcurrently perform HTS autonomous processing of samplesThis innovative application of smallau ...

Project Summary Ventricular Tachycardia (VT) is a major public health problem associated with the majority of the 300,000 cases of sudden cardiac death in the United States each year. The best current therapy for VT involves drugs to reduce VT episodes plus implantation of a cardiac defibrilator (ICD) that prolongs life by terminating episodes of VT. Permanent cessation of VT can be achieved by ab ...

Summary/Abstract The overall objective of this project is to develop new, potent, selective antimalarials that act through a novel mechanism of blocking the plasmodial surface anion channel (PSAC), a previously unexploited and highly conserved plasmodial target. Human malaria is caused by five species of protozoan parasites in the genus Plasmodium. It is estimated that there are more than 200 mill ...

PROJECT SUMMARY/ABSTRACT Marijuana Breath Analyzer The overall goal of this program is a THC breath analyzer that will provide rapid, accurate, and non-invasive determination of recent marijuana use at point-of-collection testing (POCT). Authorities will obtain breath samples noninvasively as they currently do in alcohol testing and receive the results on the spot. This field device for enforcemen ...

PROJECT SUMMARY/ABSTRACT Sober Grid™ has developed a smartphone-based mobile application currently in use by over 120,000 individuals worldwide who are in, or seeking, recovery from drug and alcohol addiction. The “Grid”, as it is known, is a mobile-based, social recovery community providing rapid context- specific peer support, efficient help seeking, motivational enhancement exercises, and ...