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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Computerized Adaptive Testing Version of the ASI

    SBC: Inflexxion, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): This Phase II application proposes to continue development of the ASI-MV-CAT, a Computer Adaptive Testing edition of Inflexxion's popular Addiction Severity Index-Multimedia Version (ASI-MV). Built on the ASI, probably the most widely used adult assessment for substance use problems in the US, the ASI-MV provides a reliable, valid and cost-effective version for ...

    SBIR Phase II 2010 Department of Health and Human Services
  2. A Culture-Free Platform for Rapid Pathogen Identification

    SBC: HELIXBIND INC.            Topic: R

    DESCRIPTION provided by applicant Fungal sepsis or fungemia is a serious public health concern afflicting over patients every year in the US where almost of those do not survive In fungemia early targeted treatment is life saving and considering the rate at which the disease develops is perhaps the most crucial factor to improving outcomes Unfortunately given the time consumi ...

    SBIR Phase II 2015 Department of Health and Human Services
  3. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A High Performance Point-of-Care Device for Umbilical Cord Blood Processing

    SBC: CYTOVERA, INC.            Topic: OD

    DESCRIPTION (provided by applicant): This project aims to continue development and validation of a novel microfluidics device developed during Phase I that preserves the maximal viability, recovery, and function of cord blood hematopoietic stem cells (HSC). Allogeneic HSC transplantation is the elective treatment for over 50 life threatening diseases including leukemia and lymphoma. However due to ...

    SBIR Phase II 2014 Department of Health and Human Services
  5. A NEW METHOD FOR THE ANALYSIS OF VITAMIN D

    SBC: NOVILYTIC, LLC            Topic: 100

    DESCRIPTION provided by applicant Most clinical assays begin with blood collection in a laboratory setting The Gates foundation and many others have recognized and attempted to deal with the fact that in much of the world clinical testing is done in a primitive setting The luxury of having a phlebotomist to draw blood with a laboratory to prepare serum or plasma for analysis is not universal ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Approach for Real-time Proteomics in Live Cells

    SBC: POWERHOUSE PROTEOMIC SYSTEMS LLC            Topic: NCRR

    DESCRIPTION (provided by applicant): The ultimate goal of this SBIR project is to develop a novel proteomic system that will enable the real- time expression profiling of proteins in live murine embryonic stem (mES) cells and in differentiated cells derived there from. The first step involves the establishment of a library of fluorescent trap mES cell lines, each of which will harbor a single fluo ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. A novel pre-defined CDR library for selection of affinity reagents

    SBC: AXIOMX INC            Topic: 300

    DESCRIPTION provided by applicant The most commonly used method for generating antibodies is through immunization of animals However this method is generally low throughput expensive time consuming and the antibodies generated are not always renewable Recombinant antibodies rAb like single chain variable fragments scFv have many attractive attributes compared to polyclonal antisera ...

    SBIR Phase II 2015 Department of Health and Human Services
  8. A Novel System to Detect Falls in Real-life Conditions

    SBC: BioSensics LLC            Topic: N

    DESCRIPTION provided by applicant Falls are the leading cause of fatal and nonfatal injuries among older adults andgt years and result in $ billion in annual medical costs Medical alert devices commonly worn as a pendant can be used to signal for help in the event of a fall More recently medical alert devices with automatic fall detection functionality have been developed These de ...

    SBIR Phase II 2015 Department of Health and Human Services
  9. A potassium-ATP channel opener for prevention of contrast-induced nephropathy

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIDDK

    Contrast media (CM) induced nephropathy (CIN) remains prevalent and debilitating, the third most common cause of acute renal failure. Based on more than 80 million (M) CM injections in the USA per annum, of which 10% take place in a population highly susceptible to the development of CIN, and a unit pricing of 200 per course, we estimate the total domestic potential market equals 1.6B. At presen ...

    SBIR Phase II 2014 Department of Health and Human Services
  10. A Practical Tool for Managing the Complexity of Biologics Process Manufacturing

    SBC: ADVANCED PROCESS COMBINATORICS, INC.            Topic: 100

    DESCRIPTION provided by applicant Biologics manufacturing based on cell culture techniques represents a tremendous advance in the pharmaceutical industry The use of biological rather than chemical processes result in unique therapeutics with greater profitability a knowledge based barrier to entry and the ability to develop therapeutics targeted at specific subsets of the population i e p ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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