Award Data

DESCRIPTION provided by applicant Epidemiologic evidence has established that shift work exposure is associated with an array of adverse health consequences including increased risk of cardiovascular disease gastrointestinal disease and cancer Investigations of the mechanisms linking shift work and disease have highlighted the importance of nocturnal light exposure and the consequent ch ...

DESCRIPTION provided by applicant Physical Sciences Inc PSI proposes to demonstrate a new dual conjugate dual band approach to whole eye optical biometry We will adapt a high speed SDOCT based scanning imaging system design recently developed for corneal scleral topography for application to the whole eye That system was based upon an ellipsoidal optical scanning imaging design that pro ...

DESCRIPTION (provided by applicant): One of every five adults in the United States (46.4 million people) is affected by arthritis. Increasing the number of days individuals are free of arthritis pain is one of the Healthy People 2010 objectives. Although there are a variety of medical treatments and medications available, self-management is a critical component in helping arthritis sufferers learn ...

DESCRIPTION (provided by applicant): Soft x-ray microscopy shows enormous promise as a technique for imaging cellular structures at resolutions well beyond what can be achieved in optical microscopes, and with much simpler sample preparation than is required for electron microscopy. In addition, the lower radiation dose required (compared to electron microscopy) allows tomographic investigation of ...

DESCRIPTION provided by applicant Vasculopathy encompasses a group of vascular diseases which includes atherosclerosis a major disease with enormous societal impact Atherosclerosis is implicated in many cardiovascular diseases including myocardial infarction peripheral vascular disease and stroke Approaches have been proposed for improving diagnostics where inconclusive or misleading inf ...

DESCRIPTION provided by applicant Finding the signal processing parameter values that are most appropriate for an individual patient is one of the essential components of hearing aid fitting In common practice the hearing aid user only plays a small role in selecting these values This proposal describes a data driven method for empowering users to select their desired parameter values by adj ...

DESCRIPTION provided by applicant BioSensics LLC in collaboration with the Department of Surgery at the University of Arizona proposes to develop clinically validate and commercialize the Upper Limb Frailty Meter UFM a novel wearable technology for quantifying frailty in older trauma patients It is necessary to quantify frailty in these patients to ensure tat treatment is appropriate r ...

Greenhouse gas (GHG) emissions are primary drivers of global climate change. Hence there is a crucial need to quantify their sources and sinks. A powerful method to constrain source and sink strengths is the analysis of the relative proportions of isotopic variants of GHG’s in atmospheric samples like those collected globally by NOAA’s Cooperative Air Sampling Network. Measurements that are ca ...

DESCRIPTION provided by applicant Restoration of the balance of the free radicals nitric oxide NO and superoxide in the pulmonary vasculature may prevent life threatening perioperative pulmonary hypertension PH in children with congenital heart defects CHD undergoing surgical correction of a left to right shunt In rodent models of PH intratracheal IT administration of R a bifunct ...

DESCRIPTION (provided by applicant): The goal of this Phase IIB SBIR application is to test the Sentien cellular bioreactor product (the Sentinel ) in a first-in-man study to assess safety and preliminary efficacy. Fifteen post-cardiac surgery patients that are diagnosed with acute kidney injury and indicated for dialysis will be enrolled and connected to the Sentinel containing one of three escal ...