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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    We propose the development of a high-throughput screening platform to facilitate the discovery of lead compounds from natural product extracts (NPEs). The proposed effort encompasses (a) utilization of NPEs from novel sources (cave organisms) with rich chemical diversity, (b) development of assays for specifically identified malaria targets, and (c) development of data management and analysis tool ...

    STTR Phase I 2007 Department of DefenseArmy
  2. A Systems Biology Approach to Enable Safe Administration of Mefloquine

    SBC: CFD Research Corporation            Topic: A06T034

    Mefloquine is known to cause adverse neurological effects, possibly attributable to single nucleotide polymorphisms (SNPs). Our objective is to develop a genetic screen capable of determining the susceptibility of an individual to Mefloquine neurotoxicity. In Phase I, transcriptional profiling of primary neurons exposed to Mefloquine was used to construct an intracellular pathway model to explain ...

    STTR Phase II 2007 Department of DefenseArmy
  3. Development of Polarizable Forcefields For Ionic Liquids

    SBC: CFD Research Corporation            Topic: AF07T004

    Ionic liquids (ILs) are being considered as potential candidates for variety of applications, such as green propellants, solvents and biomedical applications. Therefore, there is a critical need to design novel ILs with desired properties. Simulation techniques, such as molecular dynamics, have the ability to predict bulk properties, such as viscosity, density and thermal conductivity, provided a ...

    STTR Phase I 2007 Department of DefenseAir Force
  4. A Computational Framework for Multiscale Simulations of Weakly Ionized Plasmas

    SBC: CFD Research Corporation            Topic: AF07T022

    The goal of the proposed research is to develop a unified computational framework integrating adequate physical models for simulating complex non-equilibrium plasmas. Plasma dynamics is characterized by disparate spatial and temporal scales each described by appropriate physical models. The project aims to classify possible scenarios and develop general recipes for clustering phase space to dynami ...

    STTR Phase I 2007 Department of DefenseAir Force
  5. Optimized Quantum Dot Superlattice Structures for Ultra-High Efficiency Photovoltaic Cells and Photodetectors

    SBC: CFD Research Corporation            Topic: AF06T026

    Higher efficiency solar cells are needed to reduce solar-array mass, volume, and cost. This project proposes: (i) Reliable, validated models for simulation, analysis, and design of Quantum Dot Superlattice (QDS) based nano-materials for high-efficiency, radiation-hardened photovoltaic cells and photodetectors; (ii) Verify and demonstrate models by experiments; (iii) Implement novel models in CFDR ...

    STTR Phase II 2007 Department of DefenseAir Force
  6. High-Fidelity Modeling Tools for Bone Conduction Communication Systems

    SBC: CFD Research Corporation            Topic: A06T033

    Warfighters increasingly rely on radio communication equipment to ensure safety, mission effectiveness, and situational awareness. Current military communication gear involves headphones and acoustic microphones. Unfortunately, headphones cover the ears and deteriorate detection and localization of ambient sounds that may be important for tactical situations. An alternative to air conduction is bo ...

    STTR Phase II 2007 Department of DefenseArmy
  7. Advanced Combat Simulation for More Effective Anti-Terrorist Operations

    SBC: John Tiller Software, Inc            Topic: AF07T023

    This proposal is for the development of an architecture for asymmetric and anti-terrorist simulations and the application of that architecture in the design and development of multiple user-friendly, PC-based, artificially intelligent asymmetric combat simulation systems. This effort will utilize a number of existing, mature computer wargames and will focus on enhancements to those game systems u ...

    STTR Phase I 2007 Department of DefenseAir Force
  8. Standoff Remote Triage Sensor Array for Robotic Casualty Extraction Systems

    SBC: PERL RESEARCH LLC            Topic: A07T040

    Each week, the U.S. Department of Defense provides an online update of American military casualties Operation Iraqi Freedom and Operation Enduring Freedom. [DefenseLink] According to this update, as of March 16, 2007, a total of 3,566 have been killed in action and 25,173 soldiers have been wounded in action. These figures represent the largest burden of casualties our military medical personnel h ...

    STTR Phase I 2007 Department of DefenseArmy
  9. Zero Condition Toolkit: Memory Forensics Capability

    SBC: Pikewerks Corporation            Topic: OSD06NC4

    ZCT is a volatile memory forensics capability. In Phase I, Pikewerks implemented cross view detection to identify both known and unknown kernel rootkits; and other activity attempting to subvert the normal operations of the operating system. In Phase II Pikewerks proposes to 1) expand collection of memory to include full RAM hibernation storage and RDMA/DMA, 2) expand characterization and analysis ...

    STTR Phase II 2007 Department of DefenseAir Force
  10. Software for Generating Geometrically and Topologically Accurate Urban Terrain Models Using Implicit Methods

    SBC: RADIANCE TECHNOLOGIES, INC.            Topic: A06T011

    Currently, the terrain models in most widespread use consist of surfaces represented explicitly as planar triangular facets connected in a continuous manner with each other (triangular irregular networks or TINs). Generally, these models are "terrain skins," that is, representations of height as a univalent function of two independent lateral variables (such as latitude and longitude). Objects wit ...

    STTR Phase II 2007 Department of DefenseArmy

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