Award Data

Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

In the Phases I and II of this SBIR project, a software product was developed, delivered and deployed at the Hill AFB CT facility for highly resolving computed tomography of aerospace components.The project was focused upon speed of execution using high-performance computer architectures.In this commercialization readiness program, the technology will be advanced to at least TRL 6 by the following ...

Numerous machine learning frameworks exist, each with highly variable support for accelerated computing (e.g. Graphics Processing Units (GPUs), Field-Programmable Gate Arrays (FPGAs), etc). A library of machine learning primitives could support the many disparate frameworks and boost the advancement of machine learning research and programs, such as those underway in the DARPA Data-Driven Discover ...

Rabies is a deadly zoonotic disease caused by rabies virusRABVand other lyssavirusesAnnuallyrabies causes approximatelyhuman deaths worldwideThe only widely accepted diagnostic test is the direct fluorescent antibodyDFAtestWhile rapid and sensitivethe DFA test requires expensivehighquality reagents and equipmentalong with trained diagnosticiansThese factors present economic and logistical barriers ...

Generation of high-resolution 3D anatomic and dynamic images without exposing patients to ionizing radiation renders MRI the preferred imaging modality for the detection of tumor extent and treatment response to neo-adjuvant and adjuvant medical therapies. The goal of this proposal is to develop a non-invasive, in vivo imaging-based platform that can repeatedly generate three-dimensional molecular ...

TBD

PROJECT SUMMARY ABSTRACTDrug Design MethodologiesChris HoM DPh DThis SBIR will develop automated software to accurately estimate drug target binding affinity and selectivityThis capability is crucial to drug discoveryyet remains elusive in all current design toolsOur technology identifies favorable candidates and distinguishes problematic ones that could exhibit side effects due to weak or non sel ...

PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

Organ on a chip tools that recapitulate human biologyphysiology and pathology are urgently needed in applied science research and drug testing to expedite discoveries while reducing research costs and animal sacrificeUnfortunatelymost products incorporating circulation mimicking perfusion are too complicated for researchers to useincompatible with many protocols and readsand low throughputOur goal ...

KDH Research andampCommunicationKDHRCsubmits this Fast Track SBIR proposal to developimplementand rigorously evaluate a culturally competentonline professional development course to prepare promotores to support low income Latino parents of children with special health care needsCSHCNas they navigate the education and health care systemsCSHCN experience poorer healthpsychosocialand academic outcom ...