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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. Diagnostic for Age-Related Macular Degeneration

    SBC: APELIOTUS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinic ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Flavonoid Compounds for the Prevention of Osteoporosis

    SBC: Aptotec, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 10 million people in the U.S. are estimated to have osteoporosis, a disease that results in over 1.5 million bone fractures a year. It is now known that the accumulation of fat cells (adipocytes) in bone marrow is a major factor contributing to age-related bone loss. Women with osteoporosis have higher numbers of marrow adipocytes than those wome ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Development of Alpha-1 Antitrypsin Gene Therapeutic as Treatment for COPD

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the U.S. and is associated with an imbalance in proteolytic activity in the lungs. Treatment is largely aimed at symptom remediation using bronchodilators and corticosteroids, but these do not treat the underlying disease process. We are developing a gene-based therapy to treat ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Genomic Miniarrays for HIV-1 Subtyping

    SBC: Weilin Biotechnology, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): HIV/AIDS is an unprecedented viral pandemic with 42 million people infected worldwide and killing more than 3 million people per year. The high mutation rate of this virus has led to the evolution of multiple circulating genotypes, which confer variable disease outcomes, transmission rates, resistance to therapy, and responses to different vaccines. Worldwide e ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Zebrafish Screen for Drug-Induced Long QT & Cyp3A

    SBC: ZYGOGEN, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Many therapeutic drugs have been withdrawn from market because they were found to cause Torsade de Pointes (TdP), a rare cardiac arrhythmia that often results in death. Because TdP is associated with prolongation of the QT interval (long QT) on electrocardiograms, new drugs must now be tested for their effect on long QT before they can be approved. Thus, assay ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Virtual Reality Treatment of PTSD and Substance Abuse

    SBC: VIRTUALLY BETTER INC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this STTR project is to develop and test a new treatment for PTSD that will use Virtual Reality Technology to simulate the traumatic event. Phase I will be directed toward developing virtual environments essential to the treatment of PTSD following terrorist incidents or disasters and conducting a preliminary study of feasibility. An overarc ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Neural cell based assays derived from human ES cells

    SBC: Aruna Biomedical, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Neurons send instructions to other cells in the form of electrical signals that allow movement, sensation, memory, learning and countless other activities that are taken for granted in daily life. Loss of neural cell function results from traumatic injuries such as gunshots wounds or car accidents and from neurodegenerative diseases. The scale of this health p ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Collaborative Virtual Combat Simulation Technology For System of Systems Research

    SBC: 3D PIPELINE SIMULATION CORP.            Topic: AF05210

    Our proposal is constructed around a mature, government-owned, distributed simulation architecture known as Joint Force Operational Readiness Combat Effectiveness Simulator (JFORCES) and a proven three-step computer-aided methodology known as Rapid Relational Modeling (RRM). The proposal includes definition, structuring and prioritizing of project goals and requirements using consensus of end-use ...

    SBIR Phase I 2005 Department of DefenseAir Force
  10. Development of an Innovative Practical UAV with no Moving Aerodynamic Control Surfaces

    SBC: Aerotonomy, Incorporated            Topic: AF05246

    Aerotonomy, Incorporated (AI) and subcontractor Georgia Tech Research Institute (GTRI) will apply the latest knowledge in circulation control and piezo-electric synthetic (zero net mass flux) jet actuators (SJAs) to develop a practical small UAV with no hinged control surfaces. In the area of flow control, low jet momentum coefficient SJAs have been used primarily as a mechanism to keep flow atta ...

    SBIR Phase I 2005 Department of DefenseAir Force

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