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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Digoxin Chiral Isolates as Improved Pharmaceuticals

    SBC: ACADEMIC PHARMACEUTICALS INC            Topic: N/A

    DESCRIPTION (provided by applicant): Digoxin is the first line pharmacologic therapy for CHF and AF. Digoxin increases cardiac contractility and blocks conduction through the AV node slowing the ventricular response to AF and thus slowing the rate of the beating ventricles permitting more time for the heart to fill. The recent Dig trial supports the use of digoxin in the treatment of CHF and the r ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. Vascular Permeability Normalization in Ischemic Stroke

    SBC: Advanced Life Sciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States and is the number one cause of adult disability. It is estimated that this clinical condition results in a cost of $30-40 billion in the U.S alone. While a large number of therapeutic agents have been investigated for the treatment of ischemic stroke, only one agent is currently approved for marke ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Transdermal Hydromorphone for Acute and Chronic Pain

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

    SBIR Phase II 2005 Department of Health and Human Services
  4. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Diagnostic for Age-Related Macular Degeneration

    SBC: APELIOTUS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinic ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Flavonoid Compounds for the Prevention of Osteoporosis

    SBC: Aptotec, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 10 million people in the U.S. are estimated to have osteoporosis, a disease that results in over 1.5 million bone fractures a year. It is now known that the accumulation of fat cells (adipocytes) in bone marrow is a major factor contributing to age-related bone loss. Women with osteoporosis have higher numbers of marrow adipocytes than those wome ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Avian transgenesis via site-directed integration

    SBC: AviGenics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are neede ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Long-term Iron Needs of Renal Transplant Recipients

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objectives of this project are to: (a) Formulate an oral iron/ascorbic acid supplement specific to the needs of renal transplant recipients (RTxRs), (b) evaluate the efficacy of oral iron/ascorbic acid supplementation to meet the iron needs of this patient population as part of their routine post-transplant (post-Tx) care, and (c) establish a cons ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Non-invasive Assessment of Insulin Resistance

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objectives of this project are to develop a novel non-invasive test of insulin resistance. The proposed test is based on the well-established principle of inverse relationship between glucose oxidation (Gox) and lipid oxidation (Lox) during cellular respiration. Because the ratio of whole-body Gox/Lox can be measured precisely after administratio ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. A Test of Iron Malabsorption in Patients with IDA

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Iron deficiency anemia (IDA) is a major problem among adults and elderly. In men and postmenopausal women, IDA is currently thought to result from gastrointestinal (GI) blood loss. Despite thorough GI tract evaluation, a significant number of patients are found to be negative for fecal occult blood (FOB) and >30% do not have lesions consistent with chronic bloo ...

    SBIR Phase I 2005 Department of Health and Human Services

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