Award Data

In this effort, nGimat will develop the capabilities to produce high-quality optical ceramic nanopowder for DoD applications such as laser and missile weapons and defense systems.Development of such capabilities will require improvements in current man...

DESCRIPTION provided by applicant Inhibikase Therapeutics is a clinical stage biopharmaceutical company that has developed a host targeted mechanism of action to treat AIDS related and drug induced progressive multifocal leukoencephalopathy PML PML is a demyelinating disease of the central nervous system and was rarely seen clinically until the era of the HIV epidemic began in the mid s During the ...

ABSTRACT: The goal of the Phase II work is to significantly advance the maturity of the IMPULSE system through the detail design, development, and comprehensive bench testing of its power and propulsion systems. The Phase I conceptual design showed that the system was able to meet the desired performance requirements for a Group 2 SUAS. This work will expand upon this Phase I design, while maintai ...

The human papillomavirus HPV E protein is needed for viral replication Infection with high risk HPV types can progress to pre malignant lesions called dysplasias which over a period of years can eventuate in invasive and metastatic epithelial malignancies HPV E proteins bind to the ubiquitin ligase E AP and this complex targets p and other E binding proteins for proteasome mediated de ...

DESCRIPTION provided by applicant Kinase inhibitors are an effective class of targeted therapy for oncology However heterogeneous patient response and acquired resistance continues to be a significant clinical and economic burden To overcome this problem drug developers are pursuing novel kinase inhibitors for existing kinase targets with new modes of inhibition and increased potency as wel ...

In this Phase I proposal resubmission KDH Research andamp Communication KDHRC proposes to develop and evaluate the Online Resource Center for Older Adults with Cochlear Implants RCCI RCCI will be an innovative web based resource center for older adults aged with cochlear implants CIs and their family members for age related hearing loss RCCI will provide high quality information ...

DESCRIPTION provided by applicant A broad goal of the proposed research is to develop personal exposure monitors comprising wearable wireless sensor arrays to detect harmful air pollutants within the breathing zone and improve the assessment of causative exposure dose response relationships in epidemiological studies Heterogeneous orthogonal detectors comprising functionalized carbon nanotub ...

DESCRIPTION provided by applicant Neural progenitor migration is an important process for the proper development and maintenance of the nervous system Derived from proliferative zones within the brain neural progenitors migrate to specific destinations guided by various extracellular cues Exposure to neurotoxicants during development can interfere with neural progenitor migration and lead to ...

DESCRIPTION provided by applicant The proposed project will create novel tablet technology for speech and language learning in minimally verbal children with autism spectrum disorder ASD This research is directly related to a goal of The National Institute on Deafness and Other Communication Disorders NIDCD which calls for andquot developing speech and language interventions for nonverbal ...

DESCRIPTION provided by applicant Chemical enhancement of CRISPR Cas mediated site specific genome engineering Abstract Programmable nucleases including Zinc Finger Nucleases TALENs meganucleases and the CRISPR Cas system allow for site specific genome engineering The ability to make targeted genetic modifications has opened up a wide variety of options for scientists in industry and aca ...