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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Transdermal Hydromorphone for Acute and Chronic Pain

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Diagnostic for Age-Related Macular Degeneration

    SBC: APELIOTUS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinic ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Flavonoid Compounds for the Prevention of Osteoporosis

    SBC: Aptotec, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 10 million people in the U.S. are estimated to have osteoporosis, a disease that results in over 1.5 million bone fractures a year. It is now known that the accumulation of fat cells (adipocytes) in bone marrow is a major factor contributing to age-related bone loss. Women with osteoporosis have higher numbers of marrow adipocytes than those wome ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Avian transgenesis via site-directed integration

    SBC: AviGenics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are neede ...

    SBIR Phase II 2005 Department of Health and Human Services
  6. A-007: Immune Modulation of HPV- Associated Neoplasia

    SBC: DEKK-TEC INC            Topic: N/A

    DESCRIPTION (provided by applicant): 4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) was originally developed as an immune modulator of immune deficiency associated cancerous growths. In a recent study, A-007 was administered as a topical gel to treat anogenital cancers associated with the human papillomavirus (HPV). There were no local or systemic toxicities and excellent responses ...

    SBIR Phase II 2005 Department of Health and Human Services
  7. Development of Alpha-1 Antitrypsin Gene Therapeutic as Treatment for COPD

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the U.S. and is associated with an imbalance in proteolytic activity in the lungs. Treatment is largely aimed at symptom remediation using bronchodilators and corticosteroids, but these do not treat the underlying disease process. We are developing a gene-based therapy to treat ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Swept Laser Source for Optical Coherence Tomography

    SBC: MICRON OPTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Building on the success of Phase l work, this Phase ll program proposes to advance a new generation of optical coherence tomography (OCT) technology based on the swept source (SS) Fourier-domain technique. The resultant bio-medical imaging system from this work, having the combined advantages in higher image quality and speed, will potentially replace the ex ...

    SBIR Phase II 2005 Department of Health and Human Services
  9. A Predictive Model for Nuclear Transfer Reprogramming

    SBC: NuPotential, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Infigen will use SBIR grant support to develop a model for evaluating the molecular events associated with cellular reprogramming that enables early determination of a cell's probability of developing into a desired organism or tissue. No such model has been reported to date, impeding rational approaches to development of emerging health care applications depen ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. A Predictive Model for Nuclear Transfer Reprogramming

    SBC: NuPotential, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Infigen will use SBIR grant support to develop a model for evaluating the molecular events associated with cellular reprogramming that enables early determination of a cell's probability of developing into a desired organism or tissue. No such model has been reported to date, impeding rational approaches to development of emerging health care applications depen ...

    SBIR Phase II 2005 Department of Health and Human Services

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