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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Novel Acoustic Resuscitation Monitor

    SBC: Active Signal Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Currently almost half of all trauma mortality is directly or indirectly attributable to hemorrhagic shock, accounting for more than 50,000 deaths yearly in the U.S. and hundreds of billions of dollars in economic costs. Active Signal Technologies proposes to develop an Acoustic Resuscitation Monitor (ARM) for enabling non-invasive assessment of systemic perfusi ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. Web-based Training Center

    SBC: Advanced Technologies/Laboratories Intl            Topic: N/A

    DESCRIPTION (provided by applicant) The primary aim is to facilitate the development and delivery of live, interactive HAZWOPER training through the use of internet-based Advanced Training Technologies (ATT). To this end, ATL has designed the ATL Web-based Training Center as a fully integrated portal that provides synchronous and asynchronous training from one access point for all students and ...

    SBIR Phase II 2005 Department of Health and Human Services
  3. Novel Therapy for Wet Age-Related Macular Degeneration

    SBC: ADVANCED VISION THERAPIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Wet age-related macular degeneration (AMD) is the leading cause of blindness in the developed world and represents a disease with a great unmet medical need. The blindness associated with wet AMD is caused by neovascularization and treatments are aimed at inhibiting this progress. The Advanced Vision Therapies, Inc. (AVT) strategy is to combine its gene deliver ...

    SBIR Phase II 2005 Department of Health and Human Services
  4. Evaluation of Kininostatin for Treatment of Wet AMD

    SBC: ADVANCED VISION THERAPIES, INC.            Topic: N/A

    DESCRIPTION: Advanced Vision Therapies, Inc. (AVT) is developing novel therapies for ocular disorders that are the major causes of blindness in the developed world. The initial indications are the neovascular diseases, wet age-related macular degeneration and diabetic proliferative retinopathy. Disease pathophysiology is characterized by abnormal blood vessel growth in the choroid or retina resul ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. RdCVF as a novel therapeutic for retinitis pigmentosa

    SBC: ADVANCED VISION THERAPIES, INC.            Topic: N/A

    Advanced Vision Therapies, Inc. (AVT) is developing novel therapies for ocular disorders that are the major causes of blindness in the developed world. These diseases include the neovascular ocular disorders, wet age-related macular degeneration (AMD) and diabetic proliferative retinopathy, and the retinal degenerative disorders, retinitis pigmentosa (RP), and dry AMD. AVT has developed a novel le ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. New Generation of Anthrax Prophylaxis and Therapy

    SBC: AFG BIOSOLUTIONS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase I SBIR application addresses the NIAID call for high priority biodefense products such as novel vaccines and therapeutics to protect our nation against various biothreat agents. Although these types of proposals do not require a significant amount of preliminary data, we have already performed substantial preliminary experimental work that encourages ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Transdermal Hydromorphone for Acute and Chronic Pain

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Biofilm development and Eye Infections

    SBC: AMULET PHARMACEUTICALS, INC.            Topic: N/A

    Contact lens related eye infections impact millions of people yearly. Standard guidelines for lens care can minimize eye infection, but it has been shown that only about 50% of lens wearers adhere to appropriate guidelines. During usual use and storage procedures, microorganisms adhere to contact lenses. Daily lens cleaning removes most of these microorganisms, but sometimes microbes establish bio ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. An IL-2 Receptor Targeted Toxin with Reduced VLS

    SBC: ANJIN GROUP, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Well over a decade ago the first diphtheria toxin-based fusion protein toxin, DAB389IL-2 (Ontak(R)) was in development as the first of a new class of receptor specific therapeutic agent. This fusion protein gained FDA approval five years ago for the treatment of refractory cutaneous T cell lymphoma. The fusion protein toxin technology has not been widely devel ...

    SBIR Phase I 2005 Department of Health and Human Services

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