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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Transdermal Hydromorphone for Acute and Chronic Pain

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Diagnostic for Age-Related Macular Degeneration

    SBC: APELIOTUS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinic ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Flavonoid Compounds for the Prevention of Osteoporosis

    SBC: Aptotec, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 10 million people in the U.S. are estimated to have osteoporosis, a disease that results in over 1.5 million bone fractures a year. It is now known that the accumulation of fat cells (adipocytes) in bone marrow is a major factor contributing to age-related bone loss. Women with osteoporosis have higher numbers of marrow adipocytes than those wome ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Avian transgenesis via site-directed integration

    SBC: AviGenics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are neede ...

    SBIR Phase II 2005 Department of Health and Human Services
  6. Development of Alpha-1 Antitrypsin Gene Therapeutic as Treatment for COPD

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the U.S. and is associated with an imbalance in proteolytic activity in the lungs. Treatment is largely aimed at symptom remediation using bronchodilators and corticosteroids, but these do not treat the underlying disease process. We are developing a gene-based therapy to treat ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Electrokinetic Method For Single Molecule DNA Sequencing

    SBC: LI-COR BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose a new approach to single-molecule DMA sequencing that can be done in a simple microtiter plate fitted with two electrodes. Over two-hundred different single DMA molecules would be sequenced simultaneously in a single well (maximum 10 nt/s per molecule) with read lengths 20 kb or more. Sequencing cost is potentially lower with this method compared ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Metal Enhancement for a Near-IR Fluorescence Scanner

    SBC: LI-COR BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Fluorescent molecules that are in close proximity to metallic surfaces, including silver and gold island films, produce increased fluorescence intensity along with increased photostability and decreased fluorescent lifetimes. These metal island films have been largely studied for their ability to increase fluorescent intensities in low quantum yield fluorophore ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Submicron Particles and Fibers for Toxicological Studies

    SBC: LNKCHEMSOLUTIONS            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase I SBIR program is aimed at initiating a business venture dedicated to the manufacturing of nanoparticulates for toxicology research. The rate of nanotechnology R&D growth in the commercial, academic, and private sectors, appears to be outpaced only by the increasing level of concern among policy makers, Federal agencies, academic researchers and the ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Swept Laser Source for Optical Coherence Tomography

    SBC: MICRON OPTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Building on the success of Phase l work, this Phase ll program proposes to advance a new generation of optical coherence tomography (OCT) technology based on the swept source (SS) Fourier-domain technique. The resultant bio-medical imaging system from this work, having the combined advantages in higher image quality and speed, will potentially replace the ex ...

    SBIR Phase II 2005 Department of Health and Human Services

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