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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Transdermal Hydromorphone for Acute and Chronic Pain

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Biomimetic Intervertebral Fusion Devices

    SBC: Amedica Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Current interbody fusion devices for lumbar fusion need improvement owing to lower than desireable success in fusion and difficulty in postoperative assessment effusion. A promising and novel approach for intervertebral fusion is to provide a cortico-cancellous structure that can withstand spine load adequately and provide a bioactive bony ingrowth surface to e ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Diagnostic for Age-Related Macular Degeneration

    SBC: APELIOTUS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinic ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. COMMERCIALIZATION OF GRAPHICAL INTRAVENOUS DRUG DISPLAY

    SBC: APPLIED MEDICAL VISUALIZATIONS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Applied Medical Visualizations has developed a real-time graphical display showing model-based predictions of drug pharmacology (pharmacokinetics and pharmacodynamics), intended for use by anesthesiologists in the operating room. The administration of intravenous drugs improves when anesthesiologists are able to visualize model-predicted concentrations, effe ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Flavonoid Compounds for the Prevention of Osteoporosis

    SBC: Aptotec, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 10 million people in the U.S. are estimated to have osteoporosis, a disease that results in over 1.5 million bone fractures a year. It is now known that the accumulation of fat cells (adipocytes) in bone marrow is a major factor contributing to age-related bone loss. Women with osteoporosis have higher numbers of marrow adipocytes than those wome ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Avian transgenesis via site-directed integration

    SBC: AviGenics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are neede ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. REBREATHING ABSORBER TO SPEED EMERGENCE FROM ANESTHESIA

    SBC: Axon Medical Inc            Topic: N/A

    DESCRIPTION (provided by applicant): When general anesthesia is administered, anesthetics in the form of vapors are delivered to a patient in 1% to 5% concentrations. Once the surgical procedure has been completed and anesthesia is no longer administered, blood carries the inhaled anesthetic from the brain to the lungs where it is exhaled from the body. The higher the brain blood flow and the ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. High Throughput DSC for Drug Screening

    SBC: Energetic Genomics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): High-throughput screening approaches are ubiquitious in the pharmaceutical industry as part of the drug discovery process. A variety of sensors are used in these screens, the most common of which are spectroscopic. Such absorbance or fluorescence based high-throughput screens inevitably require the use of extrinsic probes to provide a signal, and often require ...

    SBIR Phase II 2005 Department of Health and Human Services
  10. Inhibition of Intestinal Heme Iron Absorption

    SBC: Frontier Scientific Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Iron overload syndromes (attributable to transfusions / dietary uptake) are a significant cause of the morbidity and mortality associated with hemochromatosis, thalasemia, and sickle cell anemia. In the developed world, 2/3 of absorbed iron is derived from heme (organic iron) rather than inorganic iron. While the mechanism by which inorganic iron is absorbed i ...

    SBIR Phase II 2005 Department of Health and Human Services

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