Award Data

DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Cells within the bone marrow are known to possess bone regenerative capacity, but they are limited in number. Increasing these osteoprogenitor cell populations through the use of ex vivo expansion technologies and combining these cells with a matri ...

The therapeutic potential of patient-specific cultured cells continues to rapidly grow for a range of medical needs, such as regenerative repair of damaged tissue, cancer, and infectious diseases. As a result, the motivation to commercialize patient-specific "cell products" is increasing rapidly as well. A large unmet need exists for the development of reliable clinical and commercial ceil manufac ...

Our proposal is constructed around a mature, government-owned, distributed simulation architecture known as Joint Force Operational Readiness Combat Effectiveness Simulator (JFORCES) and a proven three-step computer-aided methodology known as Rapid Relational Modeling (RRM). The proposal includes definition, structuring and prioritizing of project goals and requirements using consensus of end-use ...

Our goal is to deliver a integrated hybrid power management device to the special operations soldier to minimize the burden of carrying unnecessary weight due to various batteries. Our proposed device includes a programmable voltage output, simple user interface, and a modular design that allows the system to be tailored to specific mission profiles. The system will include an LCD text display t ...

WHO estimates that between 300 and 500 million new cases of malaria occur each year and annual deaths from the disease number between 2 and 3 million. Although there are several compounds known to be effective for treating malaria, including quinine, doxycycline, primaquine, azithromycin, and erythromycin, side effects associated with the oral administration of these drugs results in incomplete m ...

DESCRIPTION (provided by applicant): Current nicotine delivery patches rely on the passive diffusion of nicotine through the skin and into the fluid that surrounds the cells beneath the skin (interstitial fluid). From there, the nicotine diffuses into the capillary network, enters the blood stream, and is delivered to the brain. The nicotine is contained in a textile fiber material within the p ...

DESCRIPTION (provided by applicant): The main objective of this project is to design, fabricate and experimentally research the application of capillary x-ray optics as a means of elevating the dose rate of the radiation produced by a needle-based x-ray system. The goal is to reach the dose rate of 10 Gy/hour at a distance 5 mm from the pseudo-target. The other objective is to apply capillary ...

Aerotonomy, Incorporated (AI) and subcontractor Georgia Tech Research Institute (GTRI) will apply the latest knowledge in circulation control and piezo-electric synthetic (zero net mass flux) jet actuators (SJAs) to develop a practical small UAV with no hinged control surfaces. In the area of flow control, low jet momentum coefficient SJAs have been used primarily as a mechanism to keep flow atta ...

DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...