Award Data

Rabies is a deadly zoonotic disease caused by rabies virusRABVand other lyssavirusesAnnuallyrabies causes approximatelyhuman deaths worldwideThe only widely accepted diagnostic test is the direct fluorescent antibodyDFAtestWhile rapid and sensitivethe DFA test requires expensivehighquality reagents and equipmentalong with trained diagnosticiansThese factors present economic and logistical barriers ...

Generation of high-resolution 3D anatomic and dynamic images without exposing patients to ionizing radiation renders MRI the preferred imaging modality for the detection of tumor extent and treatment response to neo-adjuvant and adjuvant medical therapies. The goal of this proposal is to develop a non-invasive, in vivo imaging-based platform that can repeatedly generate three-dimensional molecular ...

TBD

Organ on a chip tools that recapitulate human biologyphysiology and pathology are urgently needed in applied science research and drug testing to expedite discoveries while reducing research costs and animal sacrificeUnfortunatelymost products incorporating circulation mimicking perfusion are too complicated for researchers to useincompatible with many protocols and readsand low throughputOur goal ...

KDH Research andampCommunicationKDHRCsubmits this Fast Track SBIR proposal to developimplementand rigorously evaluate a culturally competentonline professional development course to prepare promotores to support low income Latino parents of children with special health care needsCSHCNas they navigate the education and health care systemsCSHCN experience poorer healthpsychosocialand academic outcom ...

PROJECT SUMMARY Glycans have several distinct properties that make them potential disease biomarkers. Firstly, their location on cell surfaces makes them the first point of contact for cellular interactions, and thus they are crucial in the control of normal metabolic processes. Secondly, cell surface molecules are strategically exposed for surveillance by the immune system, where they may serve a ...

PROJECT SUMMARY Glycans have several distinct properties that make their development as disease biomarkers appealingFirstlytheir location on cell surfaces makes them the first point of contact for cellular interactionsand thus they are crucial in the control of normal metabolic processesand converselythey function as pathogen adhesion receptorsSecondlyspecific glycan structures that are not presen ...

KDH Research andampCommunicationKDHRCsubmits this Phase II Small Business Innovation ResearchSBIRapplication to expand and fully evaluate Cochlear Implant UniversityCIUCIU is an onlineselfadvocacy skills building resource for high school and college students with cochlear implantsCIsagedand their parentsCIU seeks to develop high school and college studentsself advocacy knowledge and skills to supp ...

PROJECT SUMMARYThe specific focus of this phase I application is to develop liver tissue targeting histone deacetylase inhibitorsHDACifor targeted hepatocellular carcinomaHCCtherapyHCC accounts for overof all liver cancers and is one of the most common types of malignanciesHCC is associated with a relatively lowyear survival rateand it is the third leading cause of cancer death globallySurgical re ...

Specific AimsThe emerging clinical success of immune checkpoint inhibitor cancer immunotherapy in the last four years has significantly extended survival of many types of human cancer patientsHowevercolorectal cancerCRCexcept for the small subsetmicrosatellite instableMSICRCstands out as one of the few human cancers where anti PDPD Limmunotherapy has been unsuccessfulThe mechanism under CRC non re ...