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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Antibody Secreting Cells (ASC) in Human Clostridium Difficile Infection, Colonization, and Reoccurrence

    SBC: MICROBPLEX, INC.            Topic: N/A

    Clostridium difficile infection (CDI) is a common nosocomial pathogen that plagues patients because of it relatively high rate of recurrence. Although diagnosis for primary CDI is very sensitive, there are not tests to predict recurrence. Recent human clinical trials show monocolonal antibodies to toxin A & B are protective for recurrent disease and some natural history studies suggest generation ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Development of Novel Targeted Therapy for Prostate Cancer

    SBC: SOPHIA BIOSCIENCE INC            Topic: NCI

    DESCRIPTION (provided by applicant): Prostate cancer (PCa) is the most diagnosed cancer among men in developed countries including the United States with significant medical cost burdens. Tremendous advances have been made in PCa screening technologies, which allow early detection and treatment. Common treatment options include radical prostatectomy, external beam radiation therapy (RT) and inters ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. VLR-CART Cancer Immunotherapy

    SBC: Novab, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): The mission of Novab is to utilize the unique properties of lamprey generated Variable Lymphocyte Receptors (VLRs) to develop effective, complementary and/or superior therapeutics to those currently derived from mammalian monoclonal antibodies (mMAbs). In the current application, we seek to initiate and demonstrate proof of concept for one commercial project w ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Improving Articulatory Precision in Neurologically Compromised Adults Using Audio

    SBC: Bionic Sciences Inc.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Improving Articulatory Precision in Neurologically Compromised Adults Using Audiovisual Biofeedback. One of the most frustrating impairments of neurological damage is the inability to communicate properly via the speechmodality due to weakness in the oral motor structures, also known as dysarthria. We propose to develop a Tongue Tracking System (TTS) that can p ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. On-chip OCT for Ophthalmology applications

    SBC: Sinoora Inc.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Sinoora Inc. proposes to develop an on-chip spectral domain-optical coherence tomography (SD-OCT) system for ophthalmic applications. Phase I will concentrate on demonstrating the passive optical components of the OCT system on a single chip. The passive components include a spectrometer, coupler and an interferometer. These on- chip components will then be int ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Antibodies to O-GlcNAc modified histones for chromatin biology and epigenetic res

    SBC: GlycoScientific, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): O-glycosylation of nuclear and cytoplasmic proteins by a single ?-N-acetyl-D-glucosamine moiety (O-GlcNAc) is a common post-translational modification that is highly dynamic and fluctuates in response to cellular stimuli. This type of glycosylation has been found on approximately a thousand human proteins to date, and is thought to be nearly as wide-spread and ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Cost-effective and high-throughput chromosomal haplotyping

    SBC: 4DGENOME, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): Haplotype is fundamental genetic information; it provides essential information for deciphering the functional and etiological roles of genetic variants. Current sequencing and genotyping technologies deliver only halfof the genetic information of each individual. They cannot deliver the other half of the information; the structural conformations of alleles or ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Novel Therapeutic Approach to Hypercholesterolemia Using Next-Generation DNA Sequ


    DESCRIPTION (provided by applicant): We have developed and completed a proof-of-principle on a new transgenic mouse model for comprehensive characterization of the antibody repertoire made in response to ovalbumin injection using surface antibody capture and next-generation DNA sequencing technologies. A more commercially valuable proof is now sought using a novel screening method with an emerging ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Myocardial blood flow quantitation with the novel F-18 Flurpiridaz PET imaging tr


    Coronary artery disease continues to be a major contributor to the cause of death in the United States. The ability to diagnosis CAD in patients at an early stage has improved over the years resulting in reducing the mortality rate. In nuclear medicine/cardiology, the SPECT and PET myocardial perfusion imaging (MPI) methods and radiopharmaceuticals used clinically over the past 10 years have offer ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. A study to improve the fit of HIV prevention methods

    SBC: THEYFIT, LLC            Topic: NICHD

    DESCRIPTION provided by applicant A policy statement by the World Health Organization notes that the male latex condom is the single most efficient available technology to reduce the transmission of HIV and other sexually transmitted infections Unfortunately despite decades of condom promotion efforts condoms usage rates remain disappointingly low Between one third and one half of men ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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