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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Transdermal Hydromorphone for Acute and Chronic Pain

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. Non-Invasive Drug Delivery by Thermal Microporation

    SBC: Altea Therapeutics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) transdermal drug delivery system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for transdermal delivery of insulin and ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Diagnostic for Age-Related Macular Degeneration

    SBC: APELIOTUS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinic ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Flavonoid Compounds for the Prevention of Osteoporosis

    SBC: Aptotec, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 10 million people in the U.S. are estimated to have osteoporosis, a disease that results in over 1.5 million bone fractures a year. It is now known that the accumulation of fat cells (adipocytes) in bone marrow is a major factor contributing to age-related bone loss. Women with osteoporosis have higher numbers of marrow adipocytes than those wome ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Neural cell based assays derived from human ES cells

    SBC: Aruna Biomedical, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Neurons send instructions to other cells in the form of electrical signals that allow movement, sensation, memory, learning and countless other activities that are taken for granted in daily life. Loss of neural cell function results from traumatic injuries such as gunshots wounds or car accidents and from neurodegenerative diseases. The scale of this health p ...

    STTR Phase I 2005 Department of Health and Human Services
  6. Avian transgenesis via site-directed integration

    SBC: AviGenics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are neede ...

    SBIR Phase II 2005 Department of Health and Human Services
  7. HaRT Training Innovation

    SBC: Cyntelix, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant) Cyntelix, Inc. in collaboration with the Hazardous Materials Training and Research Institute (HMTRI) at Kirkwood Community College will undertake the Hazard Response Technology (HaRT) Case Study Training Innovation Project. The goal of the HaRT Training Innovation Project is to construct an expert system with dynamic E-tools and semantic Web search capabilitie ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Development of Alpha-1 Antitrypsin Gene Therapeutic as Treatment for COPD

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the U.S. and is associated with an imbalance in proteolytic activity in the lungs. Treatment is largely aimed at symptom remediation using bronchodilators and corticosteroids, but these do not treat the underlying disease process. We are developing a gene-based therapy to treat ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. 3D Analysis of MR-imaged Articular Cartilage

    SBC: MEDICAL IMAGING APPLICATIONS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Osteoarthritis and articular cartilage injuries are very common, typically causing pain, swelling and reduced mobility leading to functional impairment. The treatment cost for patients suffering from these conditions are massive with an estimated annual economic cost of $65 billion in the US alone. Magnetic resonance imaging facilitates non-invasive imagin ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Swept Laser Source for Optical Coherence Tomography

    SBC: MICRON OPTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Building on the success of Phase l work, this Phase ll program proposes to advance a new generation of optical coherence tomography (OCT) technology based on the swept source (SS) Fourier-domain technique. The resultant bio-medical imaging system from this work, having the combined advantages in higher image quality and speed, will potentially replace the ex ...

    SBIR Phase II 2005 Department of Health and Human Services

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