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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IGF OT IGF TITLE CHEMO ENZYMATIC SYNTHESIS OF STRUCTURALLY DEFINED COMPLEX TYPE N GLYCANS

    SBC: CHEMILY, LLC            Topic: NCI

    Not Available

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Isotopically Labeled Glycoproteins for use as Internal Standards

    SBC: GlycoScientific, L.L.C.            Topic: 300

    DESCRIPTION provided by applicant The ability to accurately quantitate the glycan chains attached to glycoproteins has wide ranging implications Numerous studies over the past years have demonstrated that abnormal glycosylation occurs in virtually all types of human cancers and demonstrate the potential of using glycan markers in either a diagnostic or a prognostic manner The glycosylatio ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Manufacturing pathogen inactivated platelet lysate to treat corneal inflammation

    SBC: Cambium Medical Technologies LLC            Topic: N

    DESCRIPTION provided by applicant Ocular graft versus host disease O GVHD is a particularly severe and debilitating complication of allogeneic hematopoietic stem cell transplantation HSCT O GVHD develops in of patients with chronic GVHD Currently Restasis cyclosporine A is the only FDA approved prescription topical medication to treat O GVHD In Restasis had sales o ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Anti-CXCL13 mAb to mitigate prostate cancer health disparities

    SBC: JYANT Technologies, Inc.            Topic: NIMHD

    DESCRIPTION provided by applicant The most common metastatic site for hormone refractory prostate cancer HRPC PCa is bone While docetaxel can prolong the overall survival in patients with metastatic HRPC current treatments do not provide a cure Further complicating the matter HRPC is a disease that affects a variety of patients differently which can be problematic for physicians to prov ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Diagnosis of Bacterial Infections with Maltodexrins

    SBC: Microbial Medical, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant We present a new family of contrast agents based on targeting the maltodextrin transporter termed maltodextrin based imaging probes MDPs which are designed to image infections associated with implanted medical devices by fluorescent imaging The chemical structure of an MDP is composed of maltodextrins conjugated to a fluorescent dye MDPs have the potentia ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Humanization of VLR antibodies for therapeutic applications

    SBC: Novab, Inc.            Topic: 102

    DESCRIPTION provided by applicant Currently there is no FDA approved therapeutic antibody capable of depleting long lived plasma cells A plasma cell specific monoclonal antibody could be used to treat plasma cell malignancies multiple myelomas which are fatal and for which there is no effective treatment and antibody mediated autoimmune and severe allergic disease e g systemic lupus e ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Novel probes detecting ROS1,ALK and RET fusions and mutations in NSCLC

    SBC: GENETAG TECHNOLOGY, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is one of the leading causes of death worldwide and lung carcinoma is the leading cause of cancer related death Lung cancer is classified histologically as either small cell lung carcinoma SCLC of lung cancers or non small cell lung carcinoma NSCLC of lung cancers Genetic alterations driving NSCLC are known in only of cases an ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Patient-Tailored Selective Laser Melt-Fabricated Plates for Repair of Foot and Ankle Pathology

    SBC: MEDSHAPE, INC.            Topic: NIAMS

    DESCRIPTION provided by applicant The objective of this project is to develop novel patient specific geometrically complex Titanium Ti alloy plates made by additive manufacturing AM also called D printing for foot and ankle applications These plates will offer superior fixation and mechanical performance while minimizing the plate bulk volume Foot and ankle surgeries are common wh ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Shape-Memory Polymer Device for Distraction Enterogenesis to Treat Short Bowel Syndrome

    SBC: MEDSHAPE, INC.            Topic: 300

    DESCRIPTION provided by applicant Short bowel syndrome SBS results in significant morbidity and mortality in children and adults It is a chronic condition that occurs in up to i live births affects at least adults and costs more than $ billion annually in the United States SBS is caused by loss of intestinal length and thus digestive and absorptive capacity as a resu ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Novel adjuvant therapy for triple negative breast cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    DESCRIPTION provided by applicant Triple negative breast cancer TNBC is very difficult to treat and has no specific targeted therapies Chemotherapies used to treat this disease have many undesirable side effects and patients eventually relapse as a result of chemoresistance Obesity is pandemic in the US and many TNBC suffer from this as well Obesity is accompanied by high levels of leptin ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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