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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Compliant Shape Memory Polymer Device for Meniscal Repair

    SBC: MEDSHAPE, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): The objective of this project is to develop compliant meniscal repair devices based on shape memory polymers. The repair device will be inserted in a less invasive temporary shape and then triggered to expand into its permanent functional shape. Meniscus repair represents an increasingly common and critical soft-tissue based orthopedic procedure. Approximately ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Training Oral Hygiene Habits with a Game

    SBC: Big Fun Development Corp            Topic: NIDCR

    DESCRIPTION (provided by applicant): An epidemic of dental disease afflicts the United States. Twenty-nine percent of Americans have untreated caries. Methods to prevent this disease are well understood. Application of these methods presents a challenge tothe public health system. Most ongoing public health efforts address the problem at one of three points: (1) use of fluoride to remineralize tee ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Advanced GST Proteomics for Early Stage Organ-Specific Toxicity Screening

    SBC: OXFORD BIOMEDICAL RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Current biomarkers employed in the detection of organ toxicity are often not sensitive enough to detect the early stages of acute organ damage, i.e. at a stage when reducing or eliminating exposure to a toxin could prevent progression of organ damage or a disease process. By the time current toxicity biomarkers are detected in biological fluids there is already ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION

    SBC: ORIGINUS, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Metabolism of administered drugs is determined by expression and activity of drug-metabolizing enzymes, such as cytochrome (CYP) P450 enzymes. These P450s are subject to inhibition and sometimes induction by xenobiotics, leading to possible pharmacokinetic drug-drug interactions between co-administrated drugs. Recognizing the problem, the FDA has issued a Draft ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Development of Pluripotent Amniotic Stem Cell Banks for Disease Modeling

    SBC: TECHTOWN VENTURES,, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Direct reprogramming of somatic cells with the transcription factors Oct4 (also called Pou5f1), Sox2, Klf4 and Myc1 yields induced Pluripotent Stem (iPS) cells with marked similarity to Embryonic Stem (ES) cells. When the source of the cells is patients affected by various disorders iPS cells promise to be excellent models to study the gradual pathogenesis ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Model-Based Software for Configuring Single-Switch Scanning Systems

    SBC: Koester Performance Research            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall goal of this work is to improve outcomes for people who use single-switch scanning. Single-switch scanning is used by individuals with severe motor and communicative disabilities as a method for entering text and data into computers and augmentative communication devices. The text entry rate (TER) with single-switch scanning can be less than one wo ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. A Neonatal Cerebral Blood Flow Monitor based on MEMS Ultrasound

    SBC: SONETICS ULTRASOUND, INC            Topic: NICHD

    DESCRIPTION (provided by applicant): The goal of the proposed program is to address several technical feasibility questions (in Phase I), and then demonstrate (in a subsequent Phase II) a safe, compact patch-like monitoring device for directly measuring blood flow to the brain in very low birth weight (VLBW, lt 1500gm) infants. In Phase I, the accuracy of 3D Doppler techniques will be evaluated fo ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Mitral Valve Repair Device

    SBC: Michigan Critical Care Consultants, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Mitral valve regurgitation is a serious condition related to heart disease. The most common and effective surgical method for treating this disease is with the use of an annuloplasty ring, which reduces the size of a dilated mitral valve to restore normal function. Many patients do not receive this procedure, however, either because they are too sick to undergo ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. NOVEL, LONG-TERM PERCUTANEOUS ACCESS DEVICE FOR CHRONIC THERAPY

    SBC: VIADERM, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): A novel, next-generation percutaneous access device (PAD) will be developed for the delivery of chronic and life-sustaining therapies requiring long-term access through the skin. PAD success requirements include skin tissue integration upon implantation providing the opportunity for prolonged, stable, infection-free access. This new design includes the incorpor ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Phosphodiesterase Type IV (PDE4) Isoform Selective Allosteric Modulators For Psyc

    SBC: TETRA DISCOVERY PARTNERS, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): The broad goal of the SBIR proposal is to understand the pharmacology of phosphodiesterase 4 (PDE4) allosteric modulation in the CNS as it relates to psychiatric disorders. We recently described the discovery of isoform-selective, allosteric modulators of PDE4D that bind to a high affinity site on an N-terminal regulatory domain known as Upstream Conserved Regi ...

    SBIR Phase I 2011 Department of Health and Human Services

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