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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IGF OT IGF TITLE CHEMO ENZYMATIC SYNTHESIS OF STRUCTURALLY DEFINED COMPLEX TYPE N GLYCANS

    SBC: CHEMILY, LLC            Topic: NCI

    Not Available

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Antibody Secretig Cells ASC in Human Colostridium difficile Infection Colonization and Recurrence

    SBC: MICROBPLEX, INC.            Topic: ODCDC

    The objective of this proposal is the creation of a method for identifying patients with hospital acquired C difficile infections likely to suffer expensive and potentially life threatening recurrences after discharge from the hospital C difficile has emerged as the biggest infectious killer of Americans as well as a multi billion drain on the health care system Most of those costs and mort ...

    SBIR Phase II 2015 Department of Health and Human Services
  3. High-specificity affinity reagents for the detection of glycan sialylation

    SBC: GLYCOSENSORS AND DIAGNOSTICS, LLC            Topic: 300

    DESCRIPTION provided by applicant Glycans have several distinct properties that make their development as disease biomarkers appealing Firstly their location on cell surfaces makes them the first point of contact for cellular interactions and thus they are crucial in the control of normal metabolic processes and conversely they function as pathogen adhesion receptors Secondly specific gl ...

    STTR Phase I 2015 Department of Health and Human Services
  4. Development of Isotopically Labeled Glycoproteins for use as Internal Standards

    SBC: GlycoScientific, L.L.C.            Topic: 300

    DESCRIPTION provided by applicant The ability to accurately quantitate the glycan chains attached to glycoproteins has wide ranging implications Numerous studies over the past years have demonstrated that abnormal glycosylation occurs in virtually all types of human cancers and demonstrate the potential of using glycan markers in either a diagnostic or a prognostic manner The glycosylatio ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Manufacturing pathogen inactivated platelet lysate to treat corneal inflammation

    SBC: Cambium Medical Technologies LLC            Topic: N

    DESCRIPTION provided by applicant Ocular graft versus host disease O GVHD is a particularly severe and debilitating complication of allogeneic hematopoietic stem cell transplantation HSCT O GVHD develops in of patients with chronic GVHD Currently Restasis cyclosporine A is the only FDA approved prescription topical medication to treat O GVHD In Restasis had sales o ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human Services
  7. Anti-CXCL13 mAb to mitigate prostate cancer health disparities

    SBC: JYANT Technologies, Inc.            Topic: NIMHD

    DESCRIPTION provided by applicant The most common metastatic site for hormone refractory prostate cancer HRPC PCa is bone While docetaxel can prolong the overall survival in patients with metastatic HRPC current treatments do not provide a cure Further complicating the matter HRPC is a disease that affects a variety of patients differently which can be problematic for physicians to prov ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Diagnosis of Bacterial Infections with Maltodexrins

    SBC: Microbial Medical, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant We present a new family of contrast agents based on targeting the maltodextrin transporter termed maltodextrin based imaging probes MDPs which are designed to image infections associated with implanted medical devices by fluorescent imaging The chemical structure of an MDP is composed of maltodextrins conjugated to a fluorescent dye MDPs have the potentia ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Humanization of VLR antibodies for therapeutic applications

    SBC: Novab, Inc.            Topic: 102

    DESCRIPTION provided by applicant Currently there is no FDA approved therapeutic antibody capable of depleting long lived plasma cells A plasma cell specific monoclonal antibody could be used to treat plasma cell malignancies multiple myelomas which are fatal and for which there is no effective treatment and antibody mediated autoimmune and severe allergic disease e g systemic lupus e ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Novel probes detecting ROS1,ALK and RET fusions and mutations in NSCLC

    SBC: GENETAG TECHNOLOGY, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is one of the leading causes of death worldwide and lung carcinoma is the leading cause of cancer related death Lung cancer is classified histologically as either small cell lung carcinoma SCLC of lung cancers or non small cell lung carcinoma NSCLC of lung cancers Genetic alterations driving NSCLC are known in only of cases an ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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