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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of novel compounds for the treatment of atrial fibrillation

    SBC: Elex Biotech, Inc            Topic: NHLBI

    DESCRIPTION provided by applicant Atrial fibrillation AF is the most prevalent type of cardiac arrhythmia in the developed world affecting million people in the United States alone a number that is expected to double by because of population aging Current pharmacological options are ineffective which may be in part because these drugs fail to target key pathogenic mechanisms Recen ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. StrikeVEMP: Automated Portable Bone-Conducted Force Stimuli for Recording Acceleration-Produced coVEMPs

    SBC: Ear And Skull Base Center, Inc.            Topic: NIDCD

    DESCRIPTION provided by applicant Each year million Americans go to health care providers because of vertigo dizziness or balance problems It is the second most common complaint heard in doctorandapos s offices and will occur in of the nationandapos s population at sometime in their lives From through of US adults aged years and older million Americans had ve ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Preclinical and neuroimmunologic study of RTL1000 for methamphetamine addiction

    SBC: Virogenomics BioDevelopment Inc            Topic: R41

    DESCRIPTION provided by applicant Methamphetamine MA dependence is associated with long term damage to regions of the brain that control cognitive and psychiatric function One third to one half of MA dependent adults experience persistent cognitive and other psychiatric disorders up to three years or longer into remission The neuropsychiatric impairments that persist following abstinence ar ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A screening assay for chemicals that affect the differentiation of human neural cells.

    SBC: Nzumbe, Inc.            Topic: NIEHS

    DESCRIPTION provided by applicant Human brain development represents a highly vulnerable time to chemical exposures because immature cells are actively undergoing differentiation into more complex cell types e g neurons astrocytes oligodendroglia to form neural circuits A major reason for this vulnerability is that neuronal differentiation requires critical time dependent changes to the ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Identifying activators of interferon regulatory factors for neuroprotection

    SBC: Neuralexo, LLC            Topic: NINDS

    DESCRIPTION provided by applicant Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of signi ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. In-home monitoring system for assessing gait using wall-mounted RF transceivers

    SBC: EMBEDRF LLC            Topic: NIA

    DESCRIPTION provided by applicant The goal of this project is to develop and evaluate a new system called GaitRF that can measure walking speed and other detailed gait parameters passively within the home The ability to move is a critical function that underlies the quality of life for elders as well as those suffering from neurologic or physical ailments Changes in aspects of gait such as wa ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Mobile Internet-based Application to Promote Positive Parenting: Parent-Net

    SBC: EFFECTIVE HUMAN SERVICES LLC            Topic: NICHD

    DESCRIPTION provided by applicant There is a strong body of evidence supporting the use of behavioral parenting strategies in dealing with child behavioral problems Empirically supported behavioral parent training protocols exist e g Barkley Eyberg Forgatch and Patterson Kazdin WebsterMStratton and Reid to teach parents how to employ these strategies but th ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Targeted Pharmacological Chaperones for Neurological Diseases

    SBC: MARKER GENE TECHNOLOGIES INC            Topic: 106

    DESCRIPTION provided by applicant This Small Business Innovation Research Phase I project aims to develop new targeted pharmacological chaperones capable of modulating enzyme degradation in the Golgi apparatus and Endoplasmic Reticulum ER of living cells and tissues If successful the proposed research will provide breakthroughs needed to advance the discovery of promising new therapies and ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Therapeutic factor XI blockade for sepsis

    SBC: Aronora, Inc            Topic: NHLBI

    DESCRIPTION provided by applicant Sepsis a detrimental systemic inflammatory and procoagulant response to infections remains a leading cause of death despite antibiotics and significant advances in disease management Antithrombotic drugs e g heparins can limit septic disseminated intravascular coagulation DIC however they can produce severe bleeding side effects and may support pathog ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Multimodal Image Analysis Software for Epilepsy

    SBC: Electrical Geodesics, Inc.            Topic: 108

    DESCRIPTION provided by applicant Epilepsy is a debilitating brain disorder and surgery is the key treatment modality for those patients whose seizures cannot be controlled medically Epilepsy surgery is complex requiring multimodal imaging data for planning and execution and image analysis software is essential for this process The overall goal of this application is to develop a robust com ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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