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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SYSTEMIC RADIONUCLIDE THERAPY TARGETED TO VEGF RECEPTORS IN TUMOR VASCULATURE

    SBC: SIBTECH, INC.            Topic: NCI

    The overall goal of this collaborative project between SibTech Inc PI Backer J and Johns Hopkins University PI Pomper M is clinical development of efficient and cost effective anti angiogenic Lu radiopharmaceutical scV Lu for VEGF receptor mediated targeting of angiogenic tumor vasculature Current very expensive anti angiogenic compounds induce transient regression of tumor vascula ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. IGF OT IGF Topic Phase I SBIR Predictive Biomarkers of Adverse Reactions to Prostate Cancer Radiotherapy

    SBC: L2 DIAGNOSTICS, LLC            Topic: NCI

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. IGF OT IGF Topic Phase I SBIR Defining normal tissue and tumor biomarkers of radiosenstivity to detect treatment

    SBC: MIRA DX, Inc.            Topic: NCI

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Engineering a phosphotyrosyl-tRNA Synthetase

    SBC: AXIOMX INC            Topic: 300

    DESCRIPTION provided by applicant Although tyrosine phosphorylation is an important controlling element in cell signaling no tRNA suppressor for phosphotyrosine pTyr incorporation has yet been made We propose to use directed molecular evolution of several aminoacyl tRNA synthetases aaRSs to identify mutations that enable binding of pTyr to the aaRS Specifically ATP molecules will be att ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Small molecule inhibitors of group II introns for treatment of fungal infections

    SBC: New England Discovery Partners, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This project will result in the development of potent new inhibitors for a novel enzyme target that is specific to the metabolism of fungi and yeast the group II self splicing intron This structurally complex and highly conserved ribozyme plays a key role in RNA processing and metabolic function of lower eukaryotes but it is not present in humans and other v ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Targeted drug delivery to tumor microenvironment

    SBC: SIBTECH, INC.            Topic: 102

    DESCRIPTION provided by applicant The goal of this project is to test the feasibility of targeted delivery of andquot re programmingandquot liposomal drugs to tumor associated macrophages TAMs TAMs are the major component of tumor microenvironment that generally supports tumor growth and interferes with anti tumor therapy These effects are significantly mediated by about of TAMs that ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. A new approach to fast, diagnostic-quality, intraoperative microscopic examination

    SBC: Applikate Technologies LLC            Topic: NIBIB

    DESCRIPTION provided by applicant The goal of this Phase I SBIR proposal from Applikate Technologies LLC is to validate and optimize RapidView a novel approach to intraoperative microscopic analysis of excised tissue Currently pathologists analyze flash frozen tissue sections to provide immediate histological evaluation of surgical excisions for million operations per year in the United ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Antifungal therapy against drug resistant fungal pathogens.

    SBC: LIFEPHARMS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Despite medical advances fungal infections still exact a heavy burden on the HIV AIDs population AIDs related fungal infections account for of all AIDs related deaths In the developed world AIDS related fungal infections are most frequently associated with Candida albicans but Aspergillus fumigatus and Cryptococcus neoformans are also common Unfortunat ...

    SBIR Phase II 2015 Department of Health and Human Services
  10. Development and Evaluation of an Automated Transfer Technology

    SBC: NEXT HEALTH, LLC            Topic: NICHD

    DESCRIPTION provided by applicant The AgileLife Patient Transfer System PTS developed and commercially deployed by Next Health LLC is an innovative new device that offers a andquot zero liftandquot solution for patients who are unable to independently transfer to and from bed The AgileLife PTS consists of a fully powered hospital bed a docking station transfer system and a manual wheelcha ...

    SBIR Phase II 2015 Department of Health and Human Services

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