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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Rapid Monitoring and Assessment of Tubercuolosis Treatment at the Point of Care Using Breath

    SBC: NanoSynth Materials and Sensors Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Problem and Significance According to the CDC global statistics nearly of the world is infected with Tuberculosis TB In million f peopled infected lived in what is considered a high burden country Countries such as India Peru China sub Saharan Africa and others have significant regions endemic for TB particularly among the lower income ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Arf6 inhibitors for the treatment of uveal melanoma

    SBC: NAVIGEN, INC.            Topic: 102

    DESCRIPTION provided by applicant Activating mutations in G proteins are the drivers of oncogenesis in numerous cancers Therefore identifying drugs that block the signaling pathways controlled by these mutations could have enormous therapeutic consequences Uveal melanoma is a prototypical G driven cancer in which about of tumors have activating mutations in one of two G encoding genes ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Targeted Intraceptor Nanoparticle for Macular Degeneration

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: N

    DESCRIPTION provided by applicant Age related macular degeneration AMD is a leading cause of blindness in United States and many other industrialized nations There are two types of AMD the andquot dryandquot and andquot wetandquot forms Dry AMD is a chronic disease that usually causes variable degree of visual impairment In contrast in wet AMD which affects of AMD patients t ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Treating Acute Lung Injury via Cytokine Signaling Blockade

    SBC: NAVIGEN, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Acute lung injury ALI and acute respiratory distress syndrome ARDS result from a common pathogenic process pulmonary injury or infection triggers an overwhelming inflammatory response andquot cytokine stormandquot that results in increased endothelial and epithelial permeability and efflux of inflammatory cells protein and water from the vascular syst ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Hand-held advanced functional imager for assessing local tissue oxygenation

    SBC: WASATCH PHOTONICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant We propose development of an advanced functional imager to assess red blood cell RBC transfusion The prototype will be tested in a functional phantom during this SBIR Phase I project The key features of the imager are the ability to quantify local tissue oxygenation with a handheld probe for easy tissue access Our preliminarily market research indicates a ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. HLS13-04 High-Content High-Throughput Screen for Diamond Blackfan Anemia Treatments

    SBC: Recursion Pharmaceuticals, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant There are thousands of rare genetic diseases that have no approved treatment Recursion Pharmaceuticals has developed a drug discovery platform that seeks to re purpose known drugs for the treatment of such diseases The platform consists of high content immunofluorescent image analysis using machine learning algorithms to identify relevant and on target chang ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Application of an efficient drug repurposing platform to identify treatments for Cornelia De Lange Syndrome

    SBC: Recursion Pharmaceuticals, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Cornelia de Lange Syndrome is a complex congenital malformations syndrome with many post natal progressive medical complications CdLS has a clear genetic cause with loss of function mutations in NIPBL accounting for over of the genetically confirmed CdLS cases The remaining cases exhibit mutations in subunits or regulators of the cohesion complex SMC S ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Protease resistant D peptide Inhibitors of Ebola Virus Entry

    SBC: NAVIGEN, INC.            Topic: R

    DESCRIPTION provided by applicant Ebola virus causes highly lethal hemorrhagic fever in humans and non human primates Since the first outbreak in there have been over natural human outbreaks with an average mortality rate near There are no approved agents to prevent or treat Ebola infection Due to ease of dissemination high lethality and ability to cause widespread panic the ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a 3D Intra-oral X-ray Imaging System

    SBC: Turner Innovations, LC            Topic: NIDCR

    DESCRIPTION provided by applicant Turner Innovations proposes to develop a D intra oral x ray imaging system for use in dental clinics Current D radiographs are often ambiguous for caries detection are not usually able to visualize fractures in a tooth and because they are plane projections they can miss tooth curvature and other anomalies important to dental diagnosis and treatment Cone ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Developing a Peripherally-Acting Peptidic Galanin Analog for Treatment of Postoperative Pain

    SBC: NAVIGEN, INC.            Topic: NIDA

    DESCRIPTION provided by applicant The development of non opioid analgesics for the control of postsurgical pain is widely acknowledged as an important goal The side effects of opioids most notably respiratory depression but also including sedation nausea constipation and sleep impairment make their use challenging and even potentially life threatening Of course the difficulties posed by ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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