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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IGF OT IGF Circulating nucleic acid based nanowell label free array technology in cancer

    SBC: DETROIT R & D, INC.            Topic: NCI

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. TruEnamel: A dental product that treats, protects, desensitizes and whitens teeth

    SBC: TruEnamel, LLC            Topic: NIDCR

    DESCRIPTION provided by applicant Dentin hypersensitivity is a painful condition affecting from of the population It is caused by the movement of fluid in the dentinal tubules and can be eliminated by occluding these patent tubules Tooth whitening is a $ billion business in America and is predicted to grow both here and abroad In this grant we propose a treatment for dentin hypers ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. PDE4B Inhibitors for Treating Brain Injury

    SBC: TETRA DISCOVERY PARTNERS, INC.            Topic: 106

    DESCRIPTION provided by applicant This proposal will develop a new small molecule drug to be advanced into human clinical trials in the chronic post TBI patient who still has chronic cognitive impairments months to years after the initial TBI According to the Centers for Disease Control approximately million Americans suffer from post TBI cognitive impairments This includes people sustai ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a heterologous bio-production system for the clinically important anti-cancer natural product compound ET-743

    SBC: ALLUVIUM BIOSCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant Ecteinascidin ET is a tetrahydroisoquinolone natural product that displays potent anti cancer activity Isolated in very low yields from the marine colonial tunicate Ecteinascidia turbinata ET has been developed by PharmaMar as a cancer chemotherapeutic agent currently marketed in Europe as trabectedin Yondelis r for the treatment of soft tiss ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS-2 Dependent Insulin Signaling Cascade.

    SBC: HOUSEY PHARMACEUTICAL RESEARCH LAB            Topic: 200

    DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS Dependent Insulin Signaling Cascade andquot Diabetes is a growing and significant global health concern Insulin Receptor Substrate IRS is a critical component in the insulin mediated s ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. L-MOD Therapy: Leukocyte Immunomodulation during Cardiopulmonary Bypass

    SBC: Innovative Biotherapies, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The Problem Cardiovascular disease is the leading cause of death in the Western world In the US nearly coronary artery bypass surgeries are performed annually with an estimated of these using the technique of cardiopulmonary bypass CPB CPB patients experience complications many of which are considered to be due to the activation of leukocytes ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Validation of packed Red Blood Cell Mechanical Fragility to Indicate Transfusion Outcomes

    SBC: Blaze Medical Devices            Topic: NHLBI

    DESCRIPTION provided by applicant Blaze Medical Devices Blaze is dedicated to improving the safety and the efficacy of the nationandapos s blood supply Blaze is developing a test to quantify the prospective efficacy of each Red Blood Cell RBC unit The need for such testing is predicated upon the adverse effects and unpredictable efficacy of transfused RBC due to inter donor variability d ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Biomimetic Membrane Device for Therapeutic Application in Chronic Heart Failure

    SBC: Innovative Biotherapies, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Cardiovascular disease is the leading cause of mortality in the US accounting for of all deaths Chronic Heart Failure CHF is now understood to be a multi system disease process which involves not only the cardiovascular system but also the renal neuroendocrine and immune systems There is no effective therapy currently available to treat the most seve ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Broad Spectrum Antiviral Nucleoside Phosphonate Analogs

    SBC: TSRL, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The Working Group for Civilian Biodefense reviewed potential biological threat agents and listed those considered to pose the greatest threat to the civilian population Variola and other orthopox DNA viruses were identified as a potential bioterrorism threat Additionally other DNA viruses are of increasing concern in a public health context due to the emerge ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Validation and Cryopreservation of Ligament Engineered from Human Bone Marrow

    SBC: STEL Technologies, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant The founders of Skeletal Tissue Engineering Laboratory Technologies LLC STEL are researchers at the University of Michigan Our research team has developed an innovative and paradigm shifting approach to ligament tissue engineering and a unique methodology for ACL replacement This tissue engineered ligament technology offers the possibility of radical impr ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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