Award Data

DESCRIPTION (provided by applicant): Cancer treatment today is in need of tumor-specific and effective therapies that do not harm the patient and thereby compromise treatment efficacy and prolong recovery time. A multi-modal therapeutic and imaging agent t hat does not damage healthy living tissue would have tremendous benefit to researchers and victims of this deadly disease. Nanomaterials have t ...

Development of a general purpose software interface between cognitive models and 3D virtual environments requires innovation and research in cognitive abstractions and interfaces, as well as a thoughtful application of software architecture and engineering principles. We propose to embed these innovative cognitive abstractions in a middleware layer that offers “plug-and-play” operation for ar ...

DESCRIPTION (provided by applicant): Autoimmune diseases are thought to arise from abnormalities in innate or adaptive immune responses and most likely have both genetic and environmental components. Diagnosis of autoimmune disease is often difficult, as t he symptoms can be relatively nonspecific. Furthermore, no available blood test can accurately exclude the possibility of an autoimmune disease ...

DESCRIPTION (provided by applicant): In less than one year the 1918 Spanish flu pandemic claimed over 20 million lives worldwide, killing 675,000 Americans, more than 10 times the number of deaths to US servicemen in World War I. A similar strain of the vi rus that caused the 1918 pandemic could today kill 2 million Americans and force 10 million to be hospitalized. Although anti-viral drugs are k ...

DESCRIPTION (provided by applicant): This project will support research and further development of a novel commercializable product designed to reduce and mitigate the psychological impact of a major disaster. The long-term objective of this project is to provide a scientifically supported, highly accessible, culturally relevant, anonymous multi- media system that fills the current gap in mental ...

DESCRIPTION (provided by applicant): Prior descriptive research has examined family involvement in residential long-term care, and a handful of nursing and psychosocial interventions have attempted to facilitate family involvement and residents' social int egration in nursing homes. However, the intensity and potential intrusiveness of these interventions may make them difficult to administer as r ...

DESCRIPTION (provided by applicant): This Phase I STTR is focused on testing the feasibility of developing a scalable, commercial health information system based on ClinfoTracker, an existing system developed in an academic setting. The proposed system can significantly impact the recognition, tracking and management of chronic diseases such as cancers. By tracking and managing activities and out ...

CompuTherm, LLC in collaboration with Oak Ridge National Laboratory proposes to develop a modeling tool that can be used to understand the effect of Ti, Zr, and Hf addition on the improvement of ductility of the (Mo) phase in the Mo-Si-B system. The tool will be developed by integrating thermodynamic modeling with mechanical testing. Thermodynamic descriptions of the Mo-Si-B-X (X=Ti, Zr, Hf) syste ...

Friction Stir Processing (FSP) has been demonstrated to generate refined microstructures, resulting in improved material properties. This has several areas of application. First, FSP can enhance the formability of the particular alloy of interest. This is especially important for the superplastic forming process, where the use of FSP can be used to create superplastic behavior at high strain r ...

DESCRIPTION (provided by applicant): The overall objective of this Phase I study is to establish the technological merit and feasibility of our proposed approach to developing and then commercializing a pair of companion prognostics for newly diagnosed non - muscle invasive Ta T1 urothelial carcinoma (UC) of the bladder that accurately predicts the relative chances of tumor recurrence and progress ...