Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Nanoemulsion-based vaccine for chronic hepatitis B virus

    SBC: Bluewillow Biologics, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is the most common cause of chronic viral liver disease worldwide. More than 370 million people are chronically infected with HBV leading to nearly one million deaths annually as a result of cirrhosis, liver failure and hepatocellular carcinoma (HCC). Currently available therapies against chronic HBV are expensive, require long-term admi ...

    STTR Phase I 2010 Department of Health and Human Services
  2. Automatic Insulin Dosage Adjustment to Improve Glycemic Control of Diabetic Patie

    SBC: HYGIEIA RESEARCH, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Diabetes has become a growing epidemic, yet treatment goals are seldom achieved, and patients endure detrimental complications. Insulin is the only dose-dependent antidiabetic medication in which most patients can accomplish balanced blood glucose levels when adequate dosages are prescribed. Nonetheless, only when insulin dosage is frequently titrated, is the f ...

    STTR Phase I 2010 Department of Health and Human Services
  3. Optimizing Operating Room Efficiency


    DESCRIPTION (provided by applicant): Optimal use of operating room (OR) personnel and resources is an important problem from multiple perspectives. Unanticipated waits and delays continue to add tremendous costs and negatively impact outcomes. There are over 55 million ambulatory and 45 million inpatient procedures performed in the U.S. annually, with increasing case complexities and patient comor ...

    STTR Phase I 2010 Department of Health and Human Services
  4. Nanocrystal Delivery of Hydrophobic Anticancer Drugs

    SBC: PDS Biotechnology Corporation            Topic: NIBIB

    DESCRIPTION (provided by applicant): Nanosystems have been extensively investigated for drug delivery; however, there is a challenge in transferring nanotechnology from research laboratories into pharmaceutical industry. The scientific basis for this proposal originated from our three-phase nanoparticle engineering (3PNE) method recently developed which includes phase 1, amorphous precipitate; p ...

    STTR Phase I 2010 Department of Health and Human Services
  5. Optimization of Protein Therapeutic Formulations


    DESCRIPTION (provided by applicant): This proposal involves the development and validation of a novel approach to improve and accelerate the discovery of biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infectious and chronic diseases. The proposed research is intended to establish a new paradigm for rapidly ...

    STTR Phase I 2010 Department of Health and Human Services
  6. Detection of mtDNA Mutations at Zeptomole Sensitivity without PCR

    SBC: GENEPROTECH,INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Mitochondrial disease caused by point mutations in mitochondrial DNA (mtDNA) can be a formidable diagnostic challenge. Because clinical presentation is variable, multisystemic, and mimics many other neurological disorders, ruling out a mtDNA etiology is difficult in patients with suspected myopathies or encephalopathies. Screening for mtDNA mutations that caus ...

    STTR Phase I 2010 Department of Health and Human Services
  7. Fluorescence Intensity-Based Scoring of Macromolecule Crystallization Plates

    SBC: IXPRESSGENES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure-function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...

    STTR Phase I 2010 Department of Health and Human Services
  8. Lentiviral Vectors for the Treatment of Fanconi Anemia

    SBC: Rimedion, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): HIV-1 based lentiviral vectors are becoming an increasingly attractive means of integrating transgenes into target cells. Vectors are in or enterning clinical trials for a diverse group of ailments, including genetic disease, AIDS and cancer. Rimedion and its research partner, Indiana University School of Medicine proposes to develop a novel lentiviral vector f ...

    STTR Phase I 2010 Department of Health and Human Services
  9. Poloxamer 188 mechanism of action in ischemic heart failure.


    DESCRIPTION (provided by applicant): This project was initiated to determine how Poloxamer-188 (P-188) improves cardiac function in ischemic heart failure (HF). While it is accepted that lack of oxygen (ischemia) results in tissue damage, the direct involvement of membrane injury in the progression of ischemic HF is a relatively novel concept. The long-term goal of this project is to establish a r ...

    STTR Phase I 2010 Department of Health and Human Services
  10. eCancer: A technological approach to symptom management from home to practice


    DESCRIPTION (provided by applicant): Over 1,437,180 patients were diagnosed with cancer in 2008; over half were solid tumors. Cancer patients experience a number of life-altering symptoms during chemotherapy. Treatments have become more aggressive, are administered in outpatient settings, and in patients' homes. Despite pretreatment supportive care regimens for anemia, neutropenia, nausea and vomi ...

    STTR Phase I 2010 Department of Health and Human Services
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