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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IGF OT IGF IN VITRO CANCER STEM CELL EXPANSION PROGRAM FOR RARE TUMOR TYPES PERIOD OF PERFORMANCE

    SBC: KIYATEC, LLC            Topic: NCI

    The overall objective of this proposal is to develop an in vitro process by which cancer stem cells CSC can be isolated from primary human tumor biopsies or tissues expanded without losing critical elements of stem cell qualities and then used for preclinical and clinical applications During this fast track proposal KIYATEC will employ an integrated functional and unbiased scientific strate ...

    SBIR Phase I 2015 Department of Health and Human Services
  2. IGF OT IGF "SBIR PHASE I NEW D HUBIOGEL CULTURE SYSTEM FOR CANCER STEM CELLS EXPANSION and ANALYSIS"

    SBC: Vivo Biosciences Inc            Topic: NCI

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. IGF OT IGF VIVO BIOSCIENCES INC

    SBC: Vivo Biosciences Inc            Topic: NCI

    Not Available

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Macromolecule Crystallization Screening Results Analysis

    SBC: IXPRESSGENES, INC.            Topic: 100

    DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Novel Membrane Protein Solubilization/Stabilization Screen

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: 100

    DESCRIPTION provided by applicant The increasing output of new integral membrane protein IMP structures is partially due to the availability of an increasing number of chemical variables such as detergents detergent like molecules lipids and solubilizing stabilizing additives It is clear that specific combinations and concentrations of these different variables are often necessary to impr ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Aminoglycoside-Nucleic Acid Conjugates for Inactivation of an Antibiotic Resistance-Conferring Aminoglycoside Sensing Riboswitch

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant The world is rapidly heading towards a pre andapos s scenario when it comes to fighting infectious disease Antimicrobial resistance is a growing problem on a global scale greatly hampering our abilities to quell worldwide epidemics such as tuberculosis and malaria as well as the simple staphylococcus infection The proposed project is significant and has ...

    SBIR Phase I 2015 Department of Health and Human Services
  7. A novel biomarker of infection in neutropenic cancer patients

    SBC: BIOPOWERTECH            Topic: NIAID

    DESCRIPTION provided by applicant Early diagnosis of an infection in neutropenic cancer patients is critical for timely treatment But the diagnosis of an infection in these patients especially at an early stage can be very challenging Therefore there is a great need for sensitive biomarkers that can rapidly predict an infection and provide possible outcomes We have already reported that s ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Immunogenicity of wild-type pig tissues after ice-free cryopreservation in genetically engineered recipients

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: R

    DESCRIPTION provided by applicant There is an inadequate supply of donated human soft tissues for a variety of surgical applications Use of the patientandapos s own tissues is often effective but is associated with morbidity or not available due to prior use or inadequate due to pre existing disease We have been developing new cryopreservation methods that avoid ice formation which damages t ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. A novel phosphodiesterase isozyme target and class of inhibitors for lung cancer

    SBC: ADT Pharmaceuticals, LLC            Topic: 102

    DESCRIPTION provided by applicant Lung cancer causes more deaths in men and women than any other cancer in the United States Late detection of disease and inability to effectively treat this malignancy with chemotherapy are the main reasons for low survival rates There is an urgent medical need to develop new molecularly targeted drugs for treating lung cancer although it has been challengin ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    DESCRIPTION provided by applicant Glioblastoma GBM is an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomide TMZ Efforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brain In contrast sensitizing GBM to TMZ is an appealin ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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