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ABSTRACT:Recent technical demonstrations in hostile fire sensing and classification have highlighted the use of costly cryogenically-cooled electro-optical sensors.While capable, these types of sensors come with a higher initial purchase price as well as high life cycle costs per platform.This activity will implement a broad area hostile fire sensing architecture that uses lower cost discrete sens ...

Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

ABSTRACT:The objective of this proposal is to design an inexpensive hypersonic test article with an associated instrumentation package capable of providing measurements necessary for advancing the understanding of aerothermal behavior in the hypersonic flow regime. Significant advances and accuracy validation within multi-physics computational science and engineering (CSE) toolsets (such as comput ...

ABSTRACT:The warfighter needs an accurate and reliable source of Position, Navigation, and Timing (PNT) when GPS is not available. Fortunately, technical advances in navigation sensors and algorithms can reduce dependence on the venerable, yet vulnerable, GPS system. Inertial sensors are becoming increasingly smaller and more accurate. Low cost, powerful embedded computing platforms enable real ti ...

DESCRIPTION provided by applicant Bacterial related marginal decay is the top reason for failure and retreatment of resin based composite restorations RBCs Retreatment of these restorations costs both the patients and insurance companies billions of dollars per year The weak point of the system is the zone known as the hybrid layer where the adhesive bonds the RBC to the dentin There are ...

DESCRIPTION provided by applicant Epilepsy is the th most common neurological disorder with in people developing epilepsy the occurrence of more than one unprovoked seizure at some point in their lifetime Unfortunately of all patients have intractable medication resistant epilepsy Thus new anti epileptic drugs AEDs that target alternative mechanisms of action are needed ...

DESCRIPTION provided by applicant More than U S patients have end stage renal disease and over utilize hemodialysis as their renal replacement modality of choice The Achilles Heel in the care of dialysis patients is the development of a functioning and durable vascular access preferably an arteriovenous fistula The annual cost of treating vascular access dysfunction totals over ...

DESCRIPTION provided by applicant More than of current drugs and a much greater fraction of those in development are fluorinated including such block busters as Prozac Lipitor and Ciprobay Steady progress over the past decade has shown magic angle spinning MAS solid state NMR ssNMR to be arguably the most powerful analytical tool for studying macro molecular structures and their ...

DESCRIPTION provided by applicant A Quad Fast MAS probe for Dramatically Improved Biomolecular Structure Determinations Abstract The last years have seen steady progress in applying magic angle spinning MAS NMR to an increasingly wide range of applications in structural biology However the methods are all far from routine and often require mg of a concentrated sample that is extrem ...

DESCRIPTION provided by applicant The goal of the Phase I study is to determine the feasibility of piloting a low cost Real Time Location System RTLS for use in healthcare based on a novel technology known as Near Field Electromagnetic The proposed QHealth system promises to support a number of healthcare applications such as equipment management workflow optimization hand hygiene complian ...