Award Data

ABSTRACT Approximately 700,000 people in the United States are diagnosed with a primary brain tumor. Of these, malignant gliomas (MGs) account for approximately 40% of all intracranial tumors, with an overall survival rate of only ~34%. Surgical resection remains the cornerstone of therapy and the extent of resection correlates with survival. Fluorescence imaging has emerged as an adjunctive techn ...

Project Summary One in three seniors die with Alzheimer’s Disease (AD) or Alzheimer’s Disease related dementias (ADRD). More than six million Americans are living with AD and by 2050 this number is projected to rise to nearly 13 million. The economic costs of AD are significant, with 355 billion in national costs for caring for people with AD and ADRD. Disconcertingly, there is also an estimat ...

Project Summary / Abstract COPD is the fourth leading global killer, in part, because of the failure of frontline medicine to detect the disease. Poor early detection leads to unfavorable outcomes and high healthcare costs. Tele-stethoscope* or “TS” is novel technology that allows acoustic data captured from ordinary mobile phones to perform robust analysis of hemodynamics and pneumodynamics. ...

The United States Department of the Navy utilizes hypersonic aerial vehicles for mission-critical applications in communication, guidance, intelligence, reconnaissance, and surveillance. These functions rely upon infrared (IR) optical signals that are transmitted via highly sensitive optoelectronics housed on the vehicles. A window protects the optoelectronics while allowing transmission of IR sig ...

Project Summary This proposal develops key aspects of an ultrasensitive pathogen detection system for rodent animal health surveillance and is in response to the NIH FOA PAR-21-225 to develop novel tools and devices for animal research facilities and to support the care of animal models. The goal of the project is to develop a microfluidic device for rapid and inexpensive pathogen detection direct ...

The paracorporeal Berlin Heart EXCOR is the only FDA-approved ventricular assist device (VAD) for pediatric patients. This pulsatile diaphragm displacement pump (DDP) is small/light weight to facilitate pediatric patient ambulation. However, EXCOR efficiency is only 50% since it withdraws and pumps blood at different times (interrupted pulsatile flow). This generates a high peak blood flow rate, w ...

PROJECT SUMMARY There is an increasing trend for children with ASD with primary behavioral challenges to be hospitalized in medical facilities because accessible behavioral support resources are not available in local communities. Unfortunately, most community-based hospitals are not well equipped to meet optimal behavioral care with families consequently experiencing prolonged/protracted hospital ...

ABSTRACT Continuous monitoring of neonatal brain development is crucial for effective management of brain injury and associated complications, thus reducing healthcare burden and costs. One rapidly developing method for early characterization of abnormal brain development is to map resting-state functional connectivity (rs-FC) across distinct regions of the brain. However, currently available neur ...

PROJECT SUMMARY / ABSTRACTThe opioid crisis is an epidemic with devastating health, social, and economic consequences for the United States. In 2020, 2.7 million people over the age of 12 were reported to suffer from opioid use disorder (OUD). The total economic burden of the opioid crisis in the US was recently estimated to be nearly $1.5 trillion. Treatment for OUD involves medication (MOUD) com ...

Continuous Fiber 3D (CF3D) manufacturing is a cutting-edge composite manufacturing technology that has the potential to enable higher-performing (e.g., specific stiffness, dimensional stability) and lower-cost (e.g., less material waste, minimized part count, reduced touch labor) structures for future Navy applications. CF3D works by combining dry fiber tows with liquid snap-curing thermoset resi ...