Award Data

ABSTRACT Vaccine adjuvants help stimulate the body to generate an immune response when co injected with an antigenthe compound for which immunity is desiredAlthough the human body is capable of producing antibodies to most injected antigensadjuvants can help boost the body s ability to mount a successful and acquired immune response to the presented targetAdjuvants have been shown to enhance immun ...

PROJECT SUMMARY Diabetes is one of the most important health issues in the worldIt is a disease that disproportionately affects low and middle income countriesNot only is diabetes a major cause of morbidity and mortalityit can devastate the finances of families and strain countriesfinancial resourcesKey components for addressing this healthcare crises include early diagnosis as well as ongoing mon ...

In this proposal, a meta model-based scaling law will be used to represent each system component. A components meta model-based scaling law describes the tradeoffs between performance metrics for that component or subsystem as a function of its ratings in relation to the system. This greatly reduces the number of degrees of freedom for each component, and at the same time, retains the information ...

ABSTRACTSignal Solutions has developed a novelnoninvasive and automated piezoelectric based sleep detection system for high throughput studies of sleep in miceand has recently expanded to rat studies as wellThe respiratory signal detected by the piezo sensor during sleep can be applied to investigate important health conditions including respiratory depression due to disease or drug useand other s ...

To address the needs of Navy to successfully produce 7000 series aluminum alloy components, Sentient proposes to develop a hybrid additive manufacturing (AM) process for this topic. Hybrid AM use a secondary process (e.g. peening, burnishing) along with primary AM process to tightly control thermal profile and stress evolution locally and globally, resulting enhanced part quality (e.g. negligible ...

Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disordersAnimal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approachesAnimal epilepsy model use typically requires expensive and labor intensive experimentationwith invasive EEG measurements ...

Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

Project Summary Abstract Universal Adherence is an emerging medical device company dedicated to improving adherence to ocular medications through innovative technical solutionsOur proposed Devers Drop DeviceDwill accurately track when a patient removes an eye drop bottle capcommunicate usage data wirelessly to a database that researchers can accessand send alerts to patients when a medication is d ...

During the Phase 1 effort, there were several achievements toward the design of grounding systems for MVDC architectures. For one, the common-mode equivalent circuit (CMEC) modeling approach that was derived at Purdue under ESRDC funding, was validated in a reduced-scale hardware setup at Purdue. The system studied consisted of a single generator, active rectifier, inverter, and propulsion machine ...

DESCRIPTION provided by applicant Perioperative hemorrhage remains the major complication of transurethral and open prostatic surgical procedures Significant blood loss from these procedures causes delayed healing and longer hospitalization which significantly increases the cost of patient care Moreover prolonged urethral catheterization due to significant post operative hematuria is one of ...