Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A novel Approach for High Rate Production of IR to IR Up-converting Nano-particles

    SBC: UES, Inc.            Topic: AF11BT24

    ABSTRACT: Phosphor materials are currently being utilized in a wide variety of applications. The requirements for phosphors have become more and more stringent with smaller and smaller particles being required. In the Phase I program UES Inc. in collaboration with Penn State University has demonstrated the feasibility of a few approaches for high rate production of high efficiency IR to IR up-con ...

    STTR Phase II 2014 Department of DefenseAir Force
  3. A Rapid assay for RNA targeted drugs: Instrumentation Supplement

    SBC: NUBAD, LLC            Topic: 300

    DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Advanced Optical Diagnostics/Modeling Platform for Plasma Assisted Combustion in Vitiated Air

    SBC: Spectral Energies, LLC            Topic: AF13AT04

    ABSTRACT: Modern gas-turbine engines designs for the next-generation warfighter need to reduce exhaust gas temperatures to reduce effective thermal footprint thereby improving the mission capability. In such situations, high-altitude engine operation is often limited by the overall combustion efficiency, lean flame blow out (LBO) limit, and combustion instabilities that results in narrower opera ...

    STTR Phase I 2014 Department of DefenseAir Force
  5. Assessing the Bite Counter as a Tool for Food Intake Monitoring: Phase II

    SBC: BITE TECHNOLOGIES, LLC            Topic: 300

    DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Brain penetrant Hsp90 inhibitors for Alzheimer's disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Compact CMOS-Compatible Optical Transceiver

    SBC: Physical Sciences Inc.            Topic: AF14AT13

    ABSTRACT: Close integration of photonic devices with silicon complementary metal-oxide semiconductor (CMOS) electronics can yield significant performance improvements in many applications. The recent development of novel integrated structures in silicon including waveguides, resonators, and photodetectors will enable dramatic reductions in size, weight, and power for components implementing compl ...

    STTR Phase I 2014 Department of DefenseAir Force
  8. Decision Making under Uncertainty for Dynamic Spectrum Access

    SBC: INFOBEYOND TECHNOLOGY, LLC            Topic: AF13AT02

    ABSTRACT: Due to scarcity of spectrum, Dynamic Spectrum Access (DSA) becomes a needed technology to improve the utilization of electromagnetic spectrum for DoD satellite communication. However, current DSA approaches are developed for terrestrial communications without addressing the unique challenges for SATCOM environments such as error-prone spectrum sensing, high mobility, and large coverage. ...

    STTR Phase I 2014 Department of DefenseAir Force
  9. Development of a clinical hemoglobin modulator

    SBC: Phoenicia Biosciences, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The thalassemias and sickle cell disease are serious genetic blood diseases which are WHO designated as a growing global health burden The disorders decrease production or alter structure of the b chain of adult hemoglobin A and are characterized by anemia chronic organ damage and early mortality HbF is another type of normal hemoglobin which is suppres ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Development of an Innovative System for Cryodeposit Mitigation and Redmediation

    SBC: Physical Sciences Inc.            Topic: AF12BT10

    ABSTRACT: Physical Sciences Inc. (PSI) and the University of Tennessee Space Institute (UTSI) will develop an innovative system to measure and control the cryodeposit layer thickness that develops on cold (~20 K) surfaces in cryogenic radiometric calibration chambers. Currently removing the cryo-layer involves a lengthy process that warms the entire cryo-system to desorb the cryo-layer that incr ...

    STTR Phase II 2014 Department of DefenseAir Force
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