Award Data

Preliminary studies have demonstrated the feasibility of a novel computational scheme which will address critical errors in the present methodology of source localization. These studies will also make it feasible to obtain source location and pattern of activity based on realistic models of the head constructed from MRI or CT imaging modalities. Potential clinical applications include functional i ...

The primary goal of this Phase I design study is to develop the design of an accelerator-based neutron source for clinical boron neutron capture therapy (BNCT) using the compact radio-frequency quadruple (RFQ) linear accelerator. This accelerator design study will be completed in collaboration with the Brain Tumor Research Center at the University of California in San Francisco (UCSF). The acceler ...

U.S. production of Halons will decrease from 28 million lbs in 1988 to zero in 1995 to meet the U.S. commitments to the Montreal Protocol. A major use of Halon 1301 is as a fire suppression flooding agent. The use of fine water mists from two-fluid atomizing nozzles is proposed as a replacement for Halon 1301 fire suppression systems, especially for Class B fuel fires. The optimum droplet size and ...

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The objective of the program is to investigate the use of parametric x-ray radiation (PXR) as a tunable, quasimonochromatic x-ray source for mammography. PXR is generated by placing natural, synthetic crystals, or multilayer structures into the path of a relativistic electron beam. The virtual photons associated with the fields of the electrons are Bragg reflected by the periodic crystal lattice a ...

A novel surface phenomenon will be explored for the quantitative detection of nucleic acid hybridization. We will construct a relatively inexpensive instrument, which can attain a sensitivity limit comparable to the existing methodologies, without the use of dyes or radioisotopes. As part of the Phase I research, we will use the existing hardware to test affinity of DNA to a specifically prepared ...

WE WILL DEVELOP AIT-082 FOR THE TREATMENT OF DEMENTIA DUE TO ALZHEIMER'S DISEASE, STROKE OR AGING. IN PHASE I, WE PLAN TO COMPLETE THE PRECLINICAL STUDIES NEEDED TO SUBMIT AN INVESTIGATION- AL NEW DRUG (IND) EXEMPTION APPLICATION TO THE FOOD AND DRUG ADMINISTRATION (FDA). SPECIFICALLY, WE WILL: (1) DETERMINE THE PRECLINICAL PHARMACODYNAMICS/ PHARMACOKINETICS OF AIT-082, (2) CONDUCT PRECLINICAL TOX ...

USING A TIME TESTED, SUCCESSFULLY IMPLEMENTED COMPUTERIZED INTEGRATED CASE MANAGEMENT INFORMATION SYSTEM AS A BASE, WE WILL DESIGN AN INTEGRATED COMPUTER-AIDED SYSTEM ENGINEERING (I-CASE) TOOL, THAT WILL (A) BE READILY ACCEPTABLE TO A WIDE VARIETY OF CASE MANAGEMENT PROFESSIONALS NATION-WIDE (B) CAN EASILY BE ADAPTED TO ACCOMODATE DIFFERENCES BETWEEN AND WITHIN SERVICE AREAS NATION-WIDE, (C) CAN E ...

This proposal describes a novel, high thrust density Detonation Wave Engine (DWE) applicable to the Mach range of 0 to 3. The geometry of this novel engine concept naturally provides for integration into a new Combined Cycle Engine with Ramjets. The concept is an intermittent combustion jet engine that harnesses travelling detonation waves to accomplish compression and chemical reaction. The goal ...

An innovative actively cooled structure concept is proposed which integrates proven cooling techniques and state-of-the-art fabrication methods to extend the maximum combustor wall temperature, thereby reducing cooling requirements and aircraft weight while improving engine performance. Specifically, CONvective and TRANspiration cooling (CONTRAN) are uniquely combined, relying on hydrogen coolant ...