Award Data

THE GOAL OF THIS RESEARCH IS TO DEVISE AUTOMATED METHODS OF ANALYZING THE AUDITORY BRAINSTEM RESPONSE (ABR) WHEN IT IS RECORDED USING THREE ORTHOGONAL CHANNELS. THE RESULTING 3- CHANNEL LISSAJOUS TRAJECTORY (3-CLT) SHOWS BOTH LINEAR AND PLANAR PORTIONS, WHICH WILL BE DETECTED USING ALGORITHMS TESTED UNDER REALISTIC CONDITIONS OF BACKGROUND NOISE. THE 3-CLT METHODOLOGY IS LIKELY TO BE MORE SENSITIV ...

THE GOAL OF THE PROPOSED RESEARCH IS TO PROVIDE THE NUCLEAR MEDICINE COMMUNITY WITH A COMPACT LINEAR ACCELERATOR (LINAC) FOR THE PRODUCTION OF THE PRINCIPAL SHORT-LIVED RADIOISOTOPES USED IN POSITRON EMISSION TOMOGRAPHY. THE DESIGN OF THIS LINAC WILL BE BASED ON EXCITING NEW TECHNOLOGIES DEVELOPED FOR A PION-GENERATING LINAC (PIGMI) AT THE LOS ALAMOS NATIONAL LABORATORY AND FUNDED BY THE NATIONAL ...

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A POWERFUL, NOW IMAGING MODALITY IDEALLY SUITED FOR THIN-SHELLED STRUCTURES BUT CONSIDERABLY MORE GENERAL IN NATURE IS PROPOSED. THE APPROACH IS BASED ON WELL- ESTABLISHED DIGITAL TOMOSYNTHESIS PRINCIPLES AND MODERN REAL-TIME DIGITAL RADIOGRAPHY TECHNIQUES. A SERIES OF COMPONENT RADIOGRAPHS OF A STRUCTURE TAKEN FROM DIFFERENCE ANGLES ARE MANIPULATED ACCORDING TO A RESTORATIVE ALGORITHM TO RECOVER ...

MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.ARMED WITH THE RESULTING DETAILED KNOWLEDGE OF THE GEOMETRICAL AND TOPOGRAPHICAL PROPERTIES OF CANDIDAS DHFR INRELATION TO THE KNOWN STRUCTURE OF THE CORRESPONDI ...

MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM PSEUDOMONAS AERUGINOSA, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS. ARMED WITH THE RESULTING DETAILED KNOWLEDGE OF THE GEOMETRICAL AND TOPOGRAPHICAL PROPERTIES OFPSEUDOMONAS DHFR IN RELATION TO THE KNOWN STRUCTURE OF THE C ...

THIS PROJECT DESCRIBES THE ISOLATION OF DNA PROBES LINKED TOTHE SITE IN THE HUMAN X CHROMOSOME INVOLVED IN FRAGILITY OF THE CHROMOSOME UNDER SOME GROWTH CONDITIONS ("FRAGILE X SITE") AND KNOWN TO BE ASSOCIATED WITH A HIGH INCIDENCE OF MENTAL RETARDATION. SUCH SEQUENCES MAY BE USEFUL IN UNDER- STANDING THE MOLECULAR DEFECTS RESPONSIBLE FOR CHROMOSOMAL FRAGILITY, IN ELUCIDATING THE PATHOGENESIS OF T ...

THE ADA LANGUAGE HAS BEEN DESIGNED FOR THE DOD AS A PRIMARY LANGUAGE FOR EMBEDDED SYSTEMS. MANY FEATURES OF ADA TEND TO MAKE EXECUTION OPERATING SYSTEM (OS)-INTENSIVE. THESE ARE I/O, MULTITASKING, EXCEPTION HANDLING, TIMESLICING, AND DYNAMIC STORAGE MANAGEMENT. IN MANY SYSTEMS THESE FUNCTIONS ARE HANDLED BY THE OS COOPERATING WITH THE LANGUAGE RUNTIME SYSTEM (LRS). CALLS TO THE OS GENERALLY FORCE ...