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THIS PROPOSAL ADDRESSES THE DEVELOPMENT OF A SOLID STATE LASER SCANNER FOR ROUTING A HIGH ENERGY LASER BEAM AMONG THE FIBER OPTIC ENERGY TRANSFER PATHS OF A LASER ORDNANCE INITIATION SYSTEM. A SOLID STATE LASER SCANNER WITH NO MOVING PARTS WILL ENABLE A MORE COMPACT AND DURABLE LASER ORDNANCE INITIATION SYSTEM. APA OPTICS' SOLID STATE LASER SCANNER UTILIZES INTERGRATED OPTIC WAVEGUIDES OF ALGAAS A ...

WE PROPOSE A PHASE I RESEARCH PROGRAM AIMED AT DEPOSITING SINGLE CRYSTAL BN FILMS OVER SAPPHIRE AND SILICON CARBIDE SUBSTRATES. OUR PLAN IS TO EMPLOY A UNIQUE PHOTO-ASSISTED SWITCHED ATOMIC LAYER EPITAXY PROCESS. THIS WE FEEL WILL REDUCE THE SINGLE CRYSTAL EPITAXY TEMPERATURE VALUES CLOSE TO 1400C. WE ALSO PROPOSE TO USE A UNIQUE MULTILAYER BUFFERING PROCEDURE TO DECREASE THE INTERFACE DEFECTS RES ...

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO IMPROVE THE SURFACE PROPERTIES OF ARTIFICIAL CORNEA OVERLAY IMPLANTS FORUSE IN REFRACTIVE SURGICAL PROCEDURES. THIS WILL BE DONE BYCOVALENTLY IMMOBILIZING CELL ADHESION PROTEINS TO THESE LENSES TO PROMOTE EPITHELIALIZATION OVER THE SYNTHETIC MATERIALS. THE SPECIFIC AIMS OF PHASE I WILL BE TO USE PROPRIETARY CHEMISTRIES TO PREPARE DERIVATIVES OF CELL AD ...

ALL SYNTHETIC MATERIALS THAT CONTACT BLOOD EXPERIENCE PROBLEMS WITH BLOOD COMPATIBILITY. THE RAPID ADSORPTION OF PLASMA PROTEINS AND SUBSEQUENT ADHERENCE AND ACTIVATION OF PLATELETS LEADS TO THROMBUS FORMATION. WHEN PATIENTS ARE IMPLANTED WITH VASCULAR DEVICES OR UNDERGO HEMODIALYSIS PROCEDURES, MAINTENANCE LEVELS OF ANTICOAGULANTS MUST BE GIVEN TO PREVENT LIFE-THREATENING CLOT FORMATIONS. HOWEVER ...

POLYMER-BASED INPLANTABLE DEVICES, SUCH AS URINARY TRACT CATHETERS, INTRAOCULAR LENSES, VASCULAR GRAFTS, AND PACEMAKER LEADS COMPRISE 80% OF ALL NON-ORTHOPEDIC IMPLANTABLE DEVICES, AND THE NUMBER IS EXPECTED TO INCREASE IN THE FUTURE. UNFORTUNATELY, POLYMER SURFACES ARE INHERENTLY SUBJECT TO ALARMINGLY HIGH DEVICE-CENTERED INFECTION RATES. SINCE SYSTEMIC TREATMENT WITH CONVENTIONAL ANTIBIOTICS DOE ...

THE MOST COMMON PROBLEM WITH CURRENT BREAST PROSTHESES IS THE DEVELOPMENT OF A CONTRACTILE FIBROUS CAPSULE. CAPSULAR CONTRACTURE PRODUCES BREAST HARDINING, PAIN, AND DISTORTION OF THE BREAST SHAPE. THIS PHASE I PROJECT WILL COMBINE TWO TYPES OF PROSTHESIS SURFACE MODIFICATIONS TO REDUCE CAPSULE FORMATION AND CONTRACTURE. FIRST, THE PROSTHESIS TO BE USED WILL HAVE A TEXTURE (POROUS) SILICONE RUBBER ...

THE NUMBER OF NUCLEIC ACIDS TO MEMBRANE FILTERS HAS PROVIDED A NUMBER OF APPLICATIONS FOR MOLECULAR HYBRIDIZATION INCLUDING THE ANALYSIS OF GENOME STRUCTURE AND FUNCTION AND DIAGNOSIS OF INFECTIOUS DISEASES AND GENETIC DISORDERS. THE SENSITIVITY AND REPRODUCIBILITY OF THE HYBRIDIZATION REACTION DEPEND ON THE PROPERTIES OF THE MEMBRANE USED. BSI HAS DEVELOPED A PROPRIETARY PHOTOIMMOBILIZATION TECHN ...

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THERE CURRENTLY EXISTS NO DEPENDABLE STETHOSCOPE FOR USE IN HIGH NOISE ENVIRONMENTS. ALL AVAILABLE MODELS SUFFER SOUND DEGRADATION AT ONE OR MORE POINTS WHEN USED IN THE PRESENCE OF HIGH AMBIENT NOISE. UNFORTUNATELY, PATIENTS IN SUCH ENVIRONMNETS ARE OFTEN CRITICALLY ILL, AND THE STETHPSCOPE REMAINS A KEY TOOL IN THER IMMEDIATE EVALUATION AND TREATMENT. ANY IMPROVEMENT IN THE PHYSICIAN'S ABILITY T ...

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