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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Stable Gene Transfer by RNA Delivery

    SBC: B-MoGen Biotechnologies Inc            Topic: NHLBI

    Abstract Non viral gene delivery is used in most biomedical laboratories for basic research and for many commercial and medical applications These include basic investigations into gene function modification of cells for the production of recombinant proteins and generation of genetically modified human cells for cancer therapy e g chimeric antigen receptor transgenic T cells However the d ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Vagus Nerve Stimulation Treatment for Asthmatic Bronchoconstriction

    SBC: ROSELLINI SCIENTIFIC, LLC            Topic: NHLBI

    Project Summary The Specific Aim of this proposal is to test the feasibility of using vagus nerve stimulation VNS for treating asthma related airway constriction that is refractory to current treatments There are approximately million people with asthma in the US About percent of these asthma sufferers experience early and late phase severe asthmatic bronchoconstriction that is refract ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Harvesting specific plant metabolites from hairy root cultures using magnetized nanoparticles

    SBC: NAPROGENIX, INC.            Topic: R

    AbstractPlant cell cultures are becoming a commercially valuable source of pharmaceuticalsparticularly those that are too complex for economical chemical synthesisFor example Phyton Biotechin Germanyhas achieved great commercial success by generating taxoids for Paclitaxel production in sterile plant cell bioreactorsHoweverthe efficiency of these systems is limited by the loss in viability of the ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Gaze Steered Microphone Array for Understanding Speech in Noisy Areas

    SBC: ADVANCED MEDICAL ELECTRONICS CORP            Topic: Y

    Project Summary Abstract Advanced Medical ElectronicsAMEproposes the development of a novel portable wireless hearing aid accessory that utilizes head pose and eye tracking of the hearing aid user to steer a microphone array in the direction of interestA common problem for hearing aid users is the difficulty of participating in conversations in a noisy environment such as at a workplace or restaur ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Validation of Novel Therapeutic Approach for Cryptococcal Meningitis

    SBC: Minnetronix Medical, Inc.            Topic: NIAID

    Validation of a Novel Therapeutic Approach for Cryptococcal Meningitis PILadShivanand and McCabeAaron Project Summary When Cryptococcus is manifested as cryptococcal meningitisCMit creates a large burden of mortality and morbidity to the patient and is very difficult for the clinician to treatThere are now an estimatedUS cases andcases of CM worldwide annuallywith estimated mortality ofper yearCM ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Experimental Gonococcal Vaccine

    SBC: THERAPYX, INC.            Topic: R

    ABSTRACT Genital tract infection with Neisseria gonorrhoeaegonorrheadoes not induce a state of specific protective immunity and it can be acquired repeatedlyDespite public health measuresthe disease persists at an unacceptably high frequencythere is no vaccine against itand resistance even to the latest generations of antibiotics continues to emergeRecent findings have revealed that Ngonorrhoeae s ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Phase II: Feasibility assessment of a novel tool for mosquito vector control: Auto-Dissemination Augmented by Males (ADAM)

    SBC: MosquitoMate, Inc            Topic: R

    Project summary abstractMosquito control remains the primary tool for combating many mosquito vectored diseasessuch as DengueChikungunyaZikaand West Nilebecause no approved vaccinetherapeutant or prophylaxis is currently available for useKey deficiencies of existing vector control methods include resistance to existing insecticides and the inability to find and treat cryptic breeding siteswhich pr ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a microperforated nanocomposite balloon for intravascular anti restenotic drug delivery

    SBC: ROSELLINI SCIENTIFIC, LLC            Topic: NHLBI

    Hemodialysis is the most common treatment for kidney failure requiring the passing of blood out of the body through a filter and back into the body Almost of hemodialysis patients undergo arteriovenous graft procedures involving the insertion of prosthetic shunts i e synthetic tubes between artery and vein particularly in the forearm With the hemodialysis patient population estimated ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. SA FasL engineered human islets as a novel product for the treatment of type diabetes

    SBC: FasCure Therapeutics LLC            Topic: NIDDK

    PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

    SBC: Koronis Biomedical Technologies Corp.            Topic: NHLBI

    Abstract In this Phase I SBIR Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume P V in rodent studies Transgenic models of heart disease have been created through hypothesis driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the develop ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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