Award Data

DESCRIPTION (provided by applicant): A Compact Soft X-Ray Microbeam Facility for Small Laboratories: Radiation due natural and manmade sources is ubiquitous; research into its effects -- both harmful and beneficial -- is a major component of the mission of the NIH and related health agencies. Radiobiological microbeams are facilities able to deliver precise radiation insults to individual cells (o ...

DESCRIPTION (provided by applicant): Prematurely born infants and term infants with congenital heart disease often develop neurogenic dysphagia, a life-threatening condition characterized by difficulty in coordinating swallowing and breathing during breast and bottle feeding, resulting in a failure to gain weight and increased risk of pneumonia or death, due to taking fluid into the lungs. ...

ABSTRACT: Full-spectrum cyber operations, including both Cyber Network Attack and Cyber Network Defense, place enormous cognitive demands on operators and teams. When demands are too high or tasks are not properly allocated, performance degrades, and missions may fail. To avoid operator overload, the USAF requires a thorough, real-time evaluation of the state of the individual and the team. Asses ...

DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living. Several studies from various research groups have shown that neuromuscular electrical stimulation (NMES), used in conjunction with a comprehensive post-su ...

Triton Systems Inc responds to the US Air Force’s need for new material technologies that will enable manufacture of advanced aviation life rafts that are up to 10% lighter, come in smaller packing cases and overcome the performance limitations of current versions at extreme temperatures such as hot and dry environments. These new life rafts will be fabricated using Triton’s novel fabric, deve ...

DESCRIPTION (provided by applicant): Speech is a complex motor behavior often disrupted by neurological dysfunction. Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders. However, the effects of DBS on speech have not been consistently positive ...

DESCRIPTION (provided by applicant): Significant advances have been made toward the development of a new generation of molecularly targeted cancer drugs, many of which are only now emerging from the pipeline. This project aims to develop a new, highly sens itive technology for detecting drug-resistance mutations in proteins which preexist prior to treatment or are acquired due to the selective pre ...

DESCRIPTION (provided by applicant): Globally, an estimated 16.2% of the human population is infected with HSV-2 including gt17% of the U.S. adult population. Genital herpes is associated with an increased risk of HIV acquisition and transmission and HSV-2infection can cause neonatal herpes with high infant mortality. HSV-2 infection in the adult population has increased substantially in the past ...

DESCRIPTION provided by applicant Globally an estimated of the human population is infected with HSV including andgt of the U S adult population Genital herpes is associated with an increased risk of HIV acquisition and transmission and HSV infection can cause neonatal herpes with high infant mortality HSV infection in the adult population has increased substantially in the ...

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...