Award Data

DESCRIPTION (provided by applicant): The indications for androgen therapy has expanded such that today, androgens are used in both men and women, and in addition to their use in treating primary (or secondary) hypogonadism the potential benefit of increasing bone mineral density, inducing greater muscle mass and strength, enhancing sexual function, and improving mood. Androgens are also being cons ...

DESCRIPTION (provided by applicant): This proposal is the Phase II renewal of an STTR award to Kardia Therapeutics undertaken in collaboration with Baylor College of Medicine (the home to Kardia's founding scientists). The project will accelerate the development and commercialization of human heart-derived cardiac progenitor cells (CPCs), to promote more effective regenerative growth in human hear ...

Solid oxide fuel cells (SOFCs) offer high efficiency, quiet operation, reduced emissions, internal fuel reformation, and fuel flexibility, however current SOFCs are restricted to predominately stationary applications based on their high operating temperatures and expensive high temperature ceramics. SOFCs that operate at low temperatures (LT) (

We propose to measure through small signal ac current injection and frequency response analysis the internal complex impedances of Lead Acid, Ni-Cd, and Li Ion batteries over various operational and environmental conditions. Correlation will be observed between the impedance variations and state of charge and state of health of the target batteries. A simplified algorithm will be developed and emb ...

Our goal of this Phase II STTR is to commercialize a platform technology of non-metallic cathodes, named polyCath, to replace air/moisture sensitive metal cathodes. These metals require a rigorous barrier encapsulation to assure device operation and longevity and require vacuum processing. Encapsulation is a major obstacle to reliable, long-lived and low-cost OLED based displays.

DESCRIPTION (provided by applicant): Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. There is a clear need for more effective therapies to treat deadly pancreatic cancer disease. MicroRNAs (miRNA or miR) are a large group of short, noncoding RNAs that control posttranscriptional gene expression in human cells, and there is increasing evidence for the exi ...

DESCRIPTION (provided by applicant): Several disorders in reproductive medicine are results of changes in smooth muscle contractile activity. Increased myometrial contraction can lead to preterm labor, which affects 12% of the US population. However, the mechanisms involved in the transition from uterine quiescence to contractility at the onset of labor are not well-known. As a result, the managem ...

ABSTRACT: To fabricate transparent ceramics composed of anisotropic laser gain media, the crystal orientations of micro-domains should be aligned identically. Current method involve application of high magnetic field. Texas Biochemicals Inc. recently developed a novel technology to produce faceted hexagonal prism c axis oriented Yb: Sr-FAP [Yb: Sr5(PO4)3F nanocrystallites and sintered into transp ...

DESCRIPTION (provided by applicant): Bacterial contamination of Dental water lines is a major concern in modern Dentistry and may cause infection in Dental patients with compromised immune systems. This includes patients with cancer, diabetes, or AIDS; cardiac patients who often require prophylactic antibiotics prior to Dental treatment; the elderly, young children, and pregnant women. Bacterial l ...

DESCRIPTION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor associated antigen (TAA) to professional antigen-presenting cells (APCs) and activate them for the generation of an effective anti-tumor immune respon ...