Award Data

DESCRIPTION (provided by applicant): Currently in 40 luminary labs around the world, 7T MR is proving to be a powerful instrument for imaging the human brain. While the same potential exists for whole-body imaging at 7T, the radiofrequency coil technologyand methods critical to realizing this potential have yet to be developed. In this proposal, we plan to solve this problem by developing the new ...

DESCRIPTION (provided by applicant): The Fontan procedure is currently standard care for patients with complex single ventricle congenital heart defects. The Fontan procedure involves the creation of a cavopulmonary (CP) shunt connecting the inferior and superior vena cava (IVC and SVC) directly to the right pulmonary artery (RPA), diverting total venous return from the IVC/SVC directly to the PA ...

DESCRIPTION (provided by applicant): Because the cardiovascular anatomy of swine is similar to humans with regard to size, morphology, relative collateral arterial supply, and the presence of a well-developed vasa vasorum, the porcine coronary arterial model is the standard for the preclinical evaluation of endovascular devices. Indeed, a consensus report concerning FDA approval of the stents reco ...

DESCRIPTION (provided by applicant): Neuro Devices, Inc. will construct a dynamic sweat test (DST) for early detection of peripheral neuropathy. Neuropathy is detected by measuring the rate and volume of sweat secreted by single sweat glands (SGs) under the control of sudomotor nerves. The test has a major advantage over other tests of nerve function because SGs are accessible for analysis on ...

DESCRIPTION: Renal transplantation is the preferred therapeutic approach for end organ failure. However, the chronic use of immunosuppressive agents is critical to prevent rejection. The drugs are costly ( 15,000-25,000/year) and have significant toxicities including opportunistic infection, an increased rate of malignancy, nephrotoxicity, and other end organ damage. The induction of donor-specifi ...

ABSTRACT: We propose to develop a light weight, compact, vibration-less and micro-scale cooler for space-mission conditions based on optical refrigeration using an all-fiber approach. Specifically, we will use a Tm+3-doped fiber laser to pump Tm+3-doped glass fibers, which provide the cooling action on the affixed heat source. The cooling fiber is attached to the heating sample e.g., EO-IR detect ...

ABSTRACT: This STTR Phase I project addresses exploit attempts being mounted against applications code and modules with vulnerabilities that need to be protected. The team's strategy is to"blacken"or isolate applications and the inter, and intra communications paths between them and the lnternet using innovative algorithms developed by Embry-Riddle Aeronautical University (ERAU). We plan to ...

ABSTRACT: The key objective of the proposal is to develop sophisticated, graphical user interface driven software tools built on fully microscopic physics to design, guide and provide feedback on growth, fabrication and evaluation of semiconductor structures that provide optical gain in the critical 2.4-4 micron wavelength window. Existing technologies are severely limited by low gain, high losse ...

ABSTRACT: The behavior of the Chalcogenide based ion-conducting memristor lends itself for use as an element in a simple neuromorphic computing circuit. The reaction of a circuit to an external stimulus may be the result of its ability to learn from previous similar, yet unrelated exposures to environmental stimulus. A highly specialized variation of the memristor, previously developed by the Ad ...

We propose to develop numerical methodologies that can be used as alternatives to standard finite-difference time-domain algorithms, and that will offer substantial reductions in numerical complexity (notably CPU-time requirements) without the need to trade-off flexibility for overall robustness. In the initial phase, we propose a two-pronged approach, in which we evaluate two alternatives: (i) a ...