Award Data

Research is proposed for the development and implementation of state of the art, reduced order nonlinear aeroelastic models for multidisciplinary/multi-fidelity optimization problems. Highly efficient and accurate aeroelastic simulation tools will be constructed based upon the mathematical formalism of optimal prediction theory and a novel implementation of a filtered harmonic balance solution met ...

DESCRIPTION (provided by applicant): Detection of ovarian cancer at Stage I results in 5-year survivals of greater than 90%; however, only 23% of ovarian cancers are diagnosed early, with 67% being diagnosed with metastatic disease. Thus, new markers are being sought to accurate identify patients with ovarian cancer, particularly in early stage. Emerging evidence suggests the potential involvement ...

The opportunity identified here is to expand the capabilities of Multicontinuum Technology (MCT) for prediction of failure initiation in complex (hybrid) composites. A successful Phase 1 project will demonstrate good correlation of MCT variables with initial failure in composites with complex multiscale reinforcement architectures. A Phase 2 project would refine the predictive capabilities, embo ...

DESCRIPTION (provided by applicant): Periodontitis represents a polymicrobial disease, in which a complex microbial ecology that matures in biofilms in the subgingival sulcus triggers a chronic immunoinflammatory lesion that destroys soft and hard tissues of the periodontium. The ability to identify therapeutics, to enable more effective control and/or prevention of gingival inflammation, is a cr ...

DESCRIPTION (provided by applicant): NaugaNeedles LLC in collaboration with researchers from Purdue University are proposing to develop an advanced new Ultra-Soft Atomic Force Microscope (USAFM). This USAFM can gently create images of soft biological samples in buffer solutions with sub-picoNewton (pN) forces and sub-nm lateral resolution. This new AFM technology will have a high-bandwidth to ensu ...

One of the greatest threats to American armed forces serving in Iraq and Afghanistan is the damage caused by mines, roadside bombs, and improvised explosive devices (IEDs). The wide variety of device types, and increasing sophistication of these weapons, presents a growing challenge to protecting U.S. warfighters. Currently, personnel vehicles are protected with thick, heavy armor that severely ...

DESCRIPTION (provided by applicant): Oral infections associated with the gingival margin and subgingival sulcus lead to host inflammatory responses. Gingivitis is primarily a response to the bacteria in plaque. This disease affects nearly everyone in the population, at some time during their life. Periodontitis is a multifactorial disease that encompasses the hard and soft tissue, microbial col ...

A new physics-based simulation capability will be developed based on high-order discretizations in both space and time for application to practical engineering problems involving complex physical phenomena and complicated geometries. The goal is to develop a tool which can accurately handle multiphysics simulations, both in analysis mode, and for design optimization purposes. The approach will r ...

To address the Navy"s need for a common, scalable, platform for multi-modal 1pA level current sensing for Electrocardiogram (ECG), Electroencephalogram (EEG), and Electrodermal Response (EDR) to be fielded as a miniature wearable device with non-contact electrodes, Sentient and the State University of New York (SUNY) propose to develop the Bioelectronic Fusion Sensor System (BioFuSenS) that will a ...

Advanced effective Micro-glider development will be conceived under this Phase I effort.