Award Data

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

DESCRIPTION provided by applicant In Phase our team was able to enhance the ABM B Alert system for use in on the road evaluations by reducing the overall profile of the hardware system introducing real time commenting for marking events in real world activities and assessing and confirming current artifact rejection algorithms for sufficiency in real world environments In addition the ...

DESCRIPTION provided by applicant In this STTR project we present EyeMark a set of advanced image analysis tools for automated computation of biomarkers for diabetic retinopathy DR using retinal fundus images Specifically we will develop tools for computation of microaneurysm MA appearance and disappearance rates jointly known as turnover rates for use as a biomarker in quantifying D ...

ABSTRACT: The U.S. Air Force has a need to develop a new class of advanced, wide field of view (WFOV) imaging sensors that sample the radiation field in multiple modes: spectral, temporal, polarization, and detailed object shape. These multimodal sensors are to be deployed on high altitude drones to enhance their intelligence, surveillance, and reconnaissance (ISR) capabilities. Smaller versions o ...

DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

DESCRIPTION provided by applicant For this Phase II STTR proposal the investigators plan to develop and commercialize the radiofrequency RF coil technology to make T body MRI possible and to translate this new technology to vastly improve T clinical MRI as well In the Phase I project leading to this proposal all specific aims were accomplished to demonstrate the feasibility of safely an ...

DESCRIPTION provided by applicant The thalassemias and sickle cell disease are serious genetic blood diseases which are WHO designated as a growing global health burden The disorders decrease production or alter structure of the b chain of adult hemoglobin A and are characterized by anemia chronic organ damage and early mortality HbF is another type of normal hemoglobin which is suppres ...

ABSTRACT: Physical Sciences Inc. (PSI) and the University of Tennessee Space Institute (UTSI) will develop an innovative system to measure and control the cryodeposit layer thickness that develops on cold (~20 K) surfaces in cryogenic radiometric calibration chambers. Currently removing the cryo-layer involves a lengthy process that warms the entire cryo-system to desorb the cryo-layer that incr ...

DESCRIPTION provided by applicant There are parathyroid glands in the neck and they are responsible for the production of parathyroid hormone which maintains calcium homeostasis throughout the body They are difficult to identify relative to the other tissues in the neck such s lymph nodes fat thyroid etc This has resulted in the incidence of accidental parathyroid removal ranging from ...

DESCRIPTION provided by applicant Non alcoholic steatohepatitis NASH is characterized by fatty changes in the liver with inflammation and hepatocellular injury that in advanced stages leads to fibrosis and cirrhosis and high mortality rates NASH is frequently associated with other common metabolic abnormalities such as insulin resistance and visceral obesity Liver transplantation is curren ...