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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Brain penetrant Hsp90 inhibitors for Alzheimer's disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Broad-Spectrum PV Devices Based on Charged Quantum Dots

    SBC: Optoelectronic Nanodevices LLC            Topic: AF13AT13

    ABSTRACT: This project addresses the need for high-efficiency broad-spectrum PV cells. The proposed original PV design is based on quantum dots with built-in charge (Q-BIC), where the dot charging is realized by selective doping of dot medium. The preliminary data demonstrate that the charged dots placed in a single p-n-junction strongly enhance harvesting and conversion of sub-bandgap photons an ...

    STTR Phase I 2014 Department of DefenseAir Force
  4. Coils for Human Whole Body Imaging at 7T

    SBC: LIFE SERVICES L.L.C.            Topic: NIBIB

    DESCRIPTION provided by applicant For this Phase II STTR proposal the investigators plan to develop and commercialize the radiofrequency RF coil technology to make T body MRI possible and to translate this new technology to vastly improve T clinical MRI as well In the Phase I project leading to this proposal all specific aims were accomplished to demonstrate the feasibility of safely an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Compact CMOS-Compatible Optical Transceiver

    SBC: Physical Sciences Inc.            Topic: AF14AT13

    ABSTRACT: Close integration of photonic devices with silicon complementary metal-oxide semiconductor (CMOS) electronics can yield significant performance improvements in many applications. The recent development of novel integrated structures in silicon including waveguides, resonators, and photodetectors will enable dramatic reductions in size, weight, and power for components implementing compl ...

    STTR Phase I 2014 Department of DefenseAir Force
  6. Computer-based Prescription Opioid Abuse Prevention for Adolescents

    SBC: HEALTHSIM, INC.            Topic: R42

    DESCRIPTION provided by applicant Recreational use of prescription opioids among adolescents is a significant and growing public health concern and has been referred to as an emerging epidemic in the U S Although a number of science based interactive drug abuse prevention programs exist focused on preventing use of non prescription drugs among youth to our knowledge no science based inter ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Decision Making under Uncertainty for Dynamic Spectrum Access

    SBC: INFOBEYOND TECHNOLOGY, LLC            Topic: AF13AT02

    ABSTRACT: Due to scarcity of spectrum, Dynamic Spectrum Access (DSA) becomes a needed technology to improve the utilization of electromagnetic spectrum for DoD satellite communication. However, current DSA approaches are developed for terrestrial communications without addressing the unique challenges for SATCOM environments such as error-prone spectrum sensing, high mobility, and large coverage. ...

    STTR Phase I 2014 Department of DefenseAir Force
  8. Development and in vitro validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 105

    DESCRIPTION provided by applicant Sanfilippo disease mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which plays importa ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a clinical hemoglobin modulator

    SBC: Phoenicia Biosciences, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The thalassemias and sickle cell disease are serious genetic blood diseases which are WHO designated as a growing global health burden The disorders decrease production or alter structure of the b chain of adult hemoglobin A and are characterized by anemia chronic organ damage and early mortality HbF is another type of normal hemoglobin which is suppres ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Development of an Antigen Capture Assay for Babesia microti

    SBC: Biopeptides, Corp            Topic: NIAID

    DESCRIPTION provided by applicant Babesia microti the primary etiologic agent of human babesiosis is a tick borne eukaryotic apicomplexan pathogen that is an increasing threat to the US public health Although B microti is primarily a tick borne pathogen it can be transmitted by transfusion of infected blood Despite the well recognized threat there is no FDA licensed test to screen donor ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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