Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

Busek Co. Inc. and Stanford University propose to develop and test an advanced high power plasma propulsion concept referred to here as a Coaxial High EnerGy Thruster, or CHENG thruster.  The thruster is first and foremost a propulsive device.  However, because the device is pulsed, compact, and efficient the plasma beam is highly condensed and energetic. For this reason, the thruster may also b ...

This program will demonstrate, for the first time, a commercial prototype high power fiber laser in the 3-5µm band, based on Agiltron chalcogenide glass infrared optical fiber technology. High power IR lasers that emit multiwatt output at various infrared wavelengths in the 212µm region are a long-standing technical challenge. Fiber lasers, widely considered the choice for almost all high power ...

CeraNova transparent polycrystalline alumina - advanced window materials for high energy propulsion.  High total transmission in the visible and the MWIR.  Submicron grains result in high hardness and strength.  High chemical resistance, thermal shock resistance, impact and erosion resistance.  Powder processing enables cost effective near-net shaping of curved parts.  Proprietary technology ...

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

DESCRIPTION (provided by applicant): The goal of this project is to develop a sonar system that can be used as a mobility aid by the visually impaired. The system will consist of an ultrasonic acoustic source using a waveform that is designed to optimize target discrimination and a pair of miniature microphones that are mounted near the ears to create natural interaural level and timing difference ...

DESCRIPTION (provided by applicant): Cardiac valve replacement using prosthetic valves is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting on cardiac output. An estimated 50,000 prosthetic valves are implanted annually in the United States, with this number increasing due to an aging population and, to ...

DESCRIPTION (provided by applicant): Despite the availability of newer antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high. Endacea, Inc. (Research Triangle Park, NC) approaches sepsis with a proprietary diagnostic/biomarker ...

DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this ...

DESCRIPTION (provided by applicant): Staphylococcus aureus is a significant human pathogen which can produce a variety of toxins, including the exotoxin, staphylococcal enterotoxin B (SEB). SEB is highly toxic in small doses, and the compact structure of this protein makes it resistant to heat and denaturation. The combination of toxicity and stability caused this toxin to be selected for weaponiz ...