Award Data

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

ALTAIR Center in cooperation with University of Rochester proposes to develop a new class of active nanophotonic devices based on quantum dots embedded into photonic crystal microstructures fabricated in silicon-on-insulator waveguides. Due to extremely strong nonlinear optical and electro-optical properties and extremely short switching times, the silicon-based photonic crystal microstructures wi ...

Advanced fiber composites are fabricated by automated 3D weaving and braiding processes. These weaving processes use tows of micron diameter fibers, to create preforms for resin infiltration. The interaction between the resin matrix and the fibers can be potentially increased by creating nanoscale features on the carbon fibers. NanoLab is expert in the synthesis of carbon nanotubes and their app ...

ABSTRACT: Modern gas-turbine engines designs for the next-generation warfighter need to reduce exhaust gas temperatures to reduce effective thermal footprint thereby improving the mission capability. In such situations, high-altitude engine operation is often limited by the overall combustion efficiency, lean flame blow out (LBO) limit, and combustion instabilities that results in narrower opera ...

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

Summary and intellectual merit. This Small Business Technology Transfer Phase I project will develop a modeling language and computational support tools for specifying, analyzing, and verifying complex distributed system designs. The overall modeling and analysis framework will provide an integrated suite of tools and methods ultimately leading to qualitative improvements in the design ...

DESCRIPTION (provided by applicant): This project will develop, evaluate and distribute an interactive multimedia program to provide interactive instruction about the human nervous system using a programmed learning format. The program will also provide extensive self-testing for the competencies to be acquired through interaction with the software program. The specific aims of the project are: A) ...

DESCRIPTION (provided by applicant): Cancer continues to be a leading cause of death in the U.S. and in many other countries. Cancers develop and spread within the body when tumor cells are not detected or destroyed by the immune system. Although certain new therapies hold promise, current cancer treatments, including chemotherapy and radiation therapy, tend to kill cells non-selectively and can ...

ABSTRACT: Phosphor materials are currently being utilized in a wide variety of applications. The requirements for phosphors have become more and more stringent with smaller and smaller particles being required. In the Phase I program UES Inc. in collaboration with Penn State University has demonstrated the feasibility of a few approaches for high rate production of high efficiency IR to IR up-con ...

DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this ...