Award Data

DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are primarily comprised of polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Unfortunately, these grafts continue to have high failure rates due to secondary complications associated with acute thromboses and incomplete, unregulated cellular prol ...

DESCRIPTION (provided by applicant): Neuro Devices, Inc. will construct a dynamic sweat test (DST) for early detection of peripheral neuropathy. Neuropathy is detected by measuring the rate and volume of sweat secreted by single sweat glands (SGs) under the control of sudomotor nerves. The test has a major advantage over other tests of nerve function because SGs are accessible for analysis on ...

ABSTRACT: Modern gas-turbine engines designs for the next-generation warfighter need to reduce exhaust gas temperatures to reduce effective thermal footprint thereby improving the mission capability. In such situations, high-altitude engine operation is often limited by the overall combustion efficiency, lean flame blow out (LBO) limit, and combustion instabilities that results in narrower opera ...

DESCRIPTION (provided by applicant): Cancer is America's second leading cause of death. Many approved cancer drugs, such as bortezomib (Velcade), are cytotoxic agents that kill normal cells as well as tumor cells. Therapeutic benefit depends on tumor cellsbeing more sensitive than normal cells, thereby allowing clinical responses to be achieved at relatively safe drug doses; however, damage t ...

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

ABSTRACT: Phosphor materials are currently being utilized in a wide variety of applications. The requirements for phosphors have become more and more stringent with smaller and smaller particles being required. In the Phase I program UES Inc. in collaboration with Penn State University has demonstrated the feasibility of a few approaches for high rate production of high efficiency IR to IR up-con ...

DESCRIPTION (provided by applicant): Infections associated with medical devices can be serious and even fatal. Catheter colonization and production of a biofilm on the surface of a catheter shortly after implantation are normally the prelude for infections. A number of antimicrobial-treated catheters have been developed to combat these infections, however, many of them have limited clinical effica ...

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) and the Surgical Navigation and Robotics Laboratory (SNR) at Brigham and Women's Hospital (BWH) propose to develop and test a Smart Template to guide transperineal targeted prostate biopsiesand subsequent therapy under magnetic resonance imaging (MRI). The project aims to solve the problem of poor diagnostic yield in prostate b ...

DESCRIPTION (provided by applicant): This project proposes to build an integrated software-based system for enhancing the accuracy of tumor change detection. The intent of the system, called AutoRegister, which is to be deployed on a clinical magnetic resonance imaging (MRI) scanner platform, is to automate the alignment of a patient's brain scan with that of a prior scan, such that subseque ...

ABSTRACT: The proposed effort is focused on the development of a novel HEL beam director system prototype composed of an array of small-size densely packed and locked in-phase (phased) fiber collimators, which can be scalable in respect to the number of sub-apertures in the array and the power delivered through a single fiber collimator. In the proposed system the basic operation functions of a ...