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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are primarily comprised of polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Unfortunately, these grafts continue to have high failure rates due to secondary complications associated with acute thromboses and incomplete, unregulated cellular prol ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  2. A Device To Quantify Sweat Of Single Sweat Glands To Diagnose Neuropathy

    SBC: Neuro Devices, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Neuro Devices, Inc. will construct a dynamic sweat test (DST) for early detection of peripheral neuropathy. Neuropathy is detected by measuring the rate and volume of sweat secreted by single sweat glands (SGs) under the control of sudomotor nerves. The test has a major advantage over other tests of nerve function because SGs are accessible for analysis on ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced Optical Diagnostics/Modeling Platform for Plasma Assisted Combustion in Vitiated Air

    SBC: SPECTRAL ENERGIES LLC            Topic: AF13AT04

    ABSTRACT: Modern gas-turbine engines designs for the next-generation warfighter need to reduce exhaust gas temperatures to reduce effective thermal footprint thereby improving the mission capability. In such situations, high-altitude engine operation is often limited by the overall combustion efficiency, lean flame blow out (LBO) limit, and combustion instabilities that results in narrower opera ...

    STTR Phase I 2014 Department of DefenseAir Force
  4. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Cancer is America's second leading cause of death. Many approved cancer drugs, such as bortezomib (Velcade), are cytotoxic agents that kill normal cells as well as tumor cells. Therapeutic benefit depends on tumor cellsbeing more sensitive than normal cells, thereby allowing clinical responses to be achieved at relatively safe drug doses; however, damage t ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  5. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. AMD-FCRx to Restore Damaged Pigment Epithelium

    SBC: REGENEREX, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world. The hallmark of the disease is retinal pigment epithelial (RPE) dysfunction with subsequent death of the foveal photoreceptors. Hematopoietic stem cells (HSC) have been demonstrated to repair damaged tissues including heart muscle and nerve under selected conditions. ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. An Integrated Software Package for the Design and Simulation of Waveguides Fabricated from Omnidirectionally Reflective Composite Dielectric Materials

    SBC: Omniguide Communications, Inc.            Topic: AF02T015

    An OmniGuide fiber is a hollow-core fiber which employs a dielectric omnidirectional mirror to keep light confined to its core. These novel fibers are ideally suited for ultra-low loss optical transmission and for flexible delivery of high power lasers. Prior to and during our Phase I effort, we have developed a wide range of tools to simulate the performance of OmniGuide fibers and related stru ...

    STTR Phase II 2005 Department of DefenseAir Force
  8. A novel Approach for High Rate Production of IR to IR Up-converting Nano-particles

    SBC: UES INC            Topic: AF11BT24

    ABSTRACT: Phosphor materials are currently being utilized in a wide variety of applications. The requirements for phosphors have become more and more stringent with smaller and smaller particles being required. In the Phase I program UES Inc. in collaboration with Penn State University has demonstrated the feasibility of a few approaches for high rate production of high efficiency IR to IR up-con ...

    STTR Phase II 2014 Department of DefenseAir Force
  9. A Novel Bioresorbable Septal Occluder

    SBC: Nmt Medical, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): There is a significant body of evidence that links patent foramen ovale with cryptogenic stroke. Furthermore, closure of the patent foramen ovale has been shown to reduce the risk of stroke in high-risk patients. Closure of a patent foramen ovale is currently done by percutaneous device closure using a septal occluder. This procedure has become standard for ver ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. A NOVEL BIS-INDOLE COMPOUND AGAINST CATHETER COLONIZATION

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Infections associated with medical devices can be serious and even fatal. Catheter colonization and production of a biofilm on the surface of a catheter shortly after implantation are normally the prelude for infections. A number of antimicrobial-treated catheters have been developed to combat these infections, however, many of them have limited clinical effica ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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